Evidence map›Paper›PMID 32039240›Full record

ReviewFrontiers in cardiovascular medicine2019

Artificial Intelligence for Cardiac Imaging-Genetics Research.

Antonio de Marvao, Timothy J W Dawes, Declan P O'Regan

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  6. Review
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  9. Review
  10. Article
  11. Review
  12. The Propagation of Racial Disparities in Cardiovascular Genomics Research.Circulation. Genomic and precision medicine · 2021
    Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Antonio de MarvaoMRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom.
Timothy J W DawesMRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom.
Declan P O'ReganMRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom.
MRC London Institute of Medical Sciences · GBImperial College London · GB

Funding

British Heart Foundation NH/17/1/32725British Heart Foundation RE/13/4/30184British Heart Foundation RG/19/6/34387Medical Research Council MC_UP_1102/19
6 · The paper itself

Abstract

Cardiovascular conditions remain the leading cause of mortality and morbidity worldwide, with genotype being a significant influence on disease risk. Cardiac imaging-genetics aims to identify and characterize the genetic variants that influence functional, physiological, and anatomical phenotypes derived from cardiovascular imaging. High-throughput DNA sequencing and genotyping have greatly accelerated genetic discovery, making variant interpretation one of the key challenges in contemporary clinical genetics. Heterogeneous, low-fidelity phenotyping and difficulties integrating and then analyzing large-scale genetic, imaging and clinical datasets using traditional statistical approaches have impeded process. Artificial intelligence (AI) methods, such as deep learning, are particularly suited to tackle the challenges of scalability and high dimensionality of data and show promise in the field of cardiac imaging-genetics. Here we review the current state of AI as applied to imaging-genetics research and discuss outstanding methodological challenges, as the field moves from pilot studies to mainstream applications, from one dimensional global descriptors to high-resolution models of whole-organ shape and function, from univariate to multivariate analysis and from candidate gene to genome-wide approaches. Finally, we consider the future directions and prospects of AI imaging-genetics for ultimately helping understand the genetic and environmental underpinnings of cardiovascular health and disease.

Indexed as

artificial intelligencecardiologycardiovascular imagingdeep learninggeneticsgenomicsimaging-geneticsmachine learning

Identifiers

PMID32039240
PMCPMC6985036
OpenAlexW3000948500

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.