Evidence map›Paper›PMID 32039692›Full record

ArticleThe journal of physiological sciences : JPS2020

Paired mechanical and electrical acupuncture of neurogenic spots induces opioid-mediated suppression of hypertension in rats.

Joo Hyun Shin, Yu Fan, Do-Hee Kim, Han Byeol Jang, Suchan Chang, Yeonhee Ryu, Jong Han Bae, Sanghag Lee, Bong Hyo Lee, Scott C Steffensen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Joo Hyun ShinDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea.
Yu FanDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea.
Do-Hee KimDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea.
Han Byeol JangDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea.
Suchan ChangDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea.
Yeonhee RyuClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, 34054, South Korea.
Jong Han BaeDepartment of Physics, Yeungnam University, Gyeongsan, Gyeongbukdo, 38541, South Korea.
Sanghag LeeTriBell Lab, Yeungnam University, Gyeongsan, Gyeongbukdo, 38541, South Korea.
Bong Hyo LeeDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea.
Scott C SteffensenDepartment of Psychology and Neuroscience, Brigham Young University, Provo, UT, 84602, USA.
Chae Ha YangDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea.
Hee Young KimDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea. hykim@dhu.ac.kr.
Daegu Haany University · KRYeungnam University · KRBrigham Young University · USKorea Institute of Oriental Medicine · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While our recent studies have suggested that effective acupoints display neurogenic inflammation and can be identified as neurogenic spots (Neuro-Sps), the optimal stimulation conditions and the underlying mechanisms remain uncharacterized. We developed a combined mechano-electrical acupuncture device (MEA) and examined the effects of acupuncture at Neuro-Sps on systolic blood pressure (BP) in a rat model of immobilization-induced hypertension (IMH) and the mediation of endogenous opioid systems in its effect. Cutaneous neurogenic spots were found mostly in the forelimb. Electrical and mechanical acupuncture of Neuro-Sps increased 22-kHz ultrasonic vocalizations (USVs), c-Fos expression and cell excitability in the midbrain and synergistically alleviated the development of hypertension following immobilization stress, which was prevented by administration of the opioid antagonist naloxone into the rostral ventrolateral medulla (rVLM). These findings suggest that mechanical and electrical stimulation at Neuro-Sps suppresses the development of hypertension via mediation of the endogenous opioid system.

Indexed as

Acupuncture PointsAcupuncture TherapyAnalgesics, OpioidAnimalsBlood PressureElectric StimulationHypertensionMaleNaloxoneNarcotic AntagonistsRatsRats, Sprague-DawleyAnalgesics, OpioidNaloxoneNarcotic AntagonistsHypertensionMechanical stimulationNeurogenic spotsOpioid systemrVLMvlPGA

Identifiers

PMID32039692
PMCPMC7005077
OpenAlexW3010706343

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.