Evidence map›Paper›PMID 32041990›Full record

ArticleScientific reports2020

Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration.

Yvette Wooff, Nilisha Fernando, Josephine H C Wong, Catherine Dietrich, Riemke Aggio-Bruce, Joshua A Chu-Tan, Avril A B Robertson, Sarah L Doyle, Si Ming Man, Riccardo Natoli

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 45 citations in OpenAlex.

  1. Altered Pannexin2 Expression in Retinal Degeneration: Insights from the P23H Mouse Model of Retinis Pigmentosa.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
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  10. Clearing the AIR: AAmerican journal of ophthalmology case reports · 2025
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  11. Combination ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yvette WooffThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID http://orcid.org/0000-0003-2074-2194
Nilisha FernandoThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Josephine H C WongThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID http://orcid.org/0000-0003-1399-9258
Catherine DietrichThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Riemke Aggio-BruceThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Joshua A Chu-TanThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Avril A B RobertsonSchool of Chemistry and Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID http://orcid.org/0000-0002-9652-8357
Sarah L DoyleDepartment of Clinical Medicine, School of Medicine, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.
Si Ming ManThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID http://orcid.org/0000-0002-5079-2857
Riccardo NatoliThe John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia. Riccardo.natoli@anu.edu.au.ORCID http://orcid.org/0000-0002-9350-0439
Australian National University · AUThe University of Queensland · AUTrinity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many investigations. In this study, we used genetic and pharmacological approaches to explore the role of the inflammasome in a mouse model of retinal degeneration. We identify that Casp1/11

Indexed as

AnimalsCaspase 1Caspases, InitiatorCells, CulturedCell SurvivalDisease Models, AnimalDisease ProgressionFemaleFuransHeterocyclic Compounds, 4 or More RingsHumansIndenesInflammasomesIntravitreal InjectionsLightMacular DegenerationCasp1 protein, mouseCasp4 protein, mouseCaspase 1Caspases, InitiatorFuransHeterocyclic Compounds, 4 or More RingsIndenesInflammasomesN-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamideNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSulfonamidesSulfones

Identifiers

PMID32041990
PMCPMC7010818
OpenAlexW3005365256

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.