ArticleAnnals of translational medicine2019
Differential expression of genes associated with T lymphocytes function in septic patients with hypoxemia challenge.
Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- RNA-Based Biomarkers for Diagnostic Discrimination of Ischemic and Hemorrhagic Stroke: A Systematic Review.Journal of clinical medicine · 2026Review
- Association between prognostic nutritional index and 90-day mortality in septic patients: a retrospective cohort study.BMC nutrition · 2025Article
- Prognostic nutritional index and 28-day mortality in elderly septic patients: A retrospective analysis based on the MIMIC database.Northern clinics of Istanbul · 2025Article
- Immune cell composition and its impact on prognosis in children with sepsis.BMC pediatrics · 2024Article
- Upregulated Proteasome Subunits in COVID-19 Patients: A Link with Hypoxemia, Lymphopenia and Inflammation.Biomolecules · 2022Article
- Clinical Value of Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio in Prediction of the Development of Sepsis-Induced Kidney Injury.Disease markers · 2022Article
- Identification of key immune genes for sepsis-induced ARDS based on bioinformatics analysis.Bioengineered · 2022Article
- Identification of circulating immune landscape in ischemic stroke based on bioinformatics methods.Frontiers in genetics · 2022Article
- A Hypoxia-Associated Prognostic Gene Signature Risk Model and Prognosis Predictors in Gliomas.Frontiers in oncology · 2021Article
- Predictive value of immune cell counts and neutrophil-to-lymphocyte ratio for 28-day mortality in patients with sepsis caused by intra-abdominal infection.Burns & trauma · 2021Article
- Interpretable machine learning models for pre- and postoperative prediction of early intra-abdominal infections after liver transplantation: a multicenter retrospective cohort study.Therapeutic advances in infectious diseaseArticle
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to assess gene expression alterations related to T lymphocytes function and explore their potential association with hypoxemia among septic patients.
methodsThis is a retrospective cohort clinical study with laboratory investigations. We studied patients enrolled in sepsis biological specimen bank from Department of Critical Care Medicine, Zhongda Hospital, fulfilling consensus criteria for sepsis without any documented immune comorbidity admitted in ICU within 48 h after onset with whole blood samples drawn within 24 h of admission. Whole genome expression by microarray assay (Human LncRNA Microarray V4.0) was compared in hypoxemia cohort versus without. Differentially expressed (DE) genes with >1 log
resultsSeptic patients (n=9) with hypoxemic phenotype held higher illness severity, serum lactate and creatine, and incidence of lymphopenia compared with non-hypoxemic group (n=6). Several gene signatures related to apoptosis, inhibitory receptors, T cell immunoreceptor, transcriptions factors, toll-like receptors and cytokine and effector molecules were upregulated in hypoxemic group. Candidate genes were identified after adjustment for age, sex and presence of lymphopenia with significantly negative correlations with partial pressure of O
conclusionsHigher illness severity and incidence of lymphopenia was observed following hypoxemia in sepsis and T cell-related gene signatures were associated with hypoxemia during sepsis.
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