Evidence map›Paper›PMID 32049582›Full record

ArticleMolecular biology of the cell2020

Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in

Masahiko Takemura, Fredrik Noborn, Jonas Nilsson, Nanako Bowden, Eriko Nakato, Sarah Baker, Tsu-Yi Su, Göran Larson, Hiroshi Nakato

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Expanding the Chondroitin Sulfate Glycoproteome - But How Far?Frontiers in cell and developmental biology · 2021
    Review
  8. Article
  9. An Overview ofFrontiers in cell and developmental biology · 2021
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Masahiko TakemuraDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455.
Fredrik NobornDepartment of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg 413 45, Sweden.
Jonas NilssonDepartment of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg 413 45, Sweden.
Nanako BowdenDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455.
Eriko NakatoDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455.
Sarah BakerDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455.
Tsu-Yi SuDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455.
Göran LarsonDepartment of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg 413 45, Sweden.
Hiroshi NakatoDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455.
University of Minnesota · USUniversity of Gothenburg · SE

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Heparan sulfate proteoglycans in signaling and developmentR35GM131688 · NIGMS · UNIVERSITY OF MINNESOTA · PI Hiroshi Nakato · 2019 to 2026
$2.6M
NIGMS NIH HHS R35 GM131688NIH HHS P40 OD010949NIH HHS P40 OD018537
6 · The paper itself

Abstract

Proteoglycans, a class of carbohydrate-modified proteins, often modulate growth factor signaling on the cell surface. However, the molecular mechanism by which proteoglycans regulate signal transduction is largely unknown. In this study, using a recently developed glycoproteomic method, we found that Windpipe (Wdp) is a novel chondroitin sulfate proteoglycan (CSPG) in

Indexed as

Amino Acid SequenceAnimalsAnimals, Genetically ModifiedChondroitin Sulfate ProteoglycansChondroitin SulfatesDrosophila melanogasterDrosophila ProteinsFemaleGene Expression Regulation, DevelopmentalGene Knockdown TechniquesHedgehog ProteinsHeparan SulfateImaginal DiscsLarvaMembrane ProteinsRNA InterferenceChondroitin Sulfate ProteoglycansChondroitin SulfatesDrosophila ProteinsHedgehog ProteinsHeparan Sulfatehh protein, DrosophilaMembrane ProteinsRNA, Small Interferingwdp protein, Drosophila

Identifiers

PMID32049582
PMCPMC7185963
OpenAlexW3006356427

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.