Evidence map›Paper›PMID 32051742›Full record

ArticleAmerican journal of translational research2020

Espin distribution as revealed by super-resolution microscopy of stereocilia.

Jieyu Qi, Liyan Zhang, Fangzhi Tan, Yan Liu, Cenfeng Chu, Weijie Zhu, Yunfeng Wang, Zengxin Qi, Renjie Chai

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Regeneration of Hair Cells in the Human Vestibular System.Frontiers in molecular neuroscience · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. A novelMolecular medicine reports · 2021
    Article
  11. Article
  12. Auditory Neuropathy as the Initial Phenotype for Patients WithFrontiers in cell and developmental biology · 2021
    Article
  13. Review
  14. Article
  15. A Model of Waardenburg Syndrome Using Patient-Derived iPSCs With aFrontiers in cell and developmental biology · 2021
    Article
  16. Article
  17. Promising Applications of Nanoparticles in the Treatment of Hearing Loss.Frontiers in cell and developmental biology · 2021
    Review
  18. Frontiers in cell and developmental biology · 2021
    Article
  19. Syndromic Deafness GeneFrontiers in cell and developmental biology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jieyu QiKey Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University Nanjing 210096, China.
Liyan ZhangKey Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University Nanjing 210096, China.
Fangzhi TaniHuman Institute, ShanghaiTech University Shanghai, China.
Yan LiuiHuman Institute, ShanghaiTech University Shanghai, China.
Cenfeng ChuiHuman Institute, ShanghaiTech University Shanghai, China.
Weijie ZhuKey Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University Nanjing 210096, China.
Yunfeng WangENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, Fudan University Shanghai 200031, China.
Zengxin QiDepartment of Neurosurgery, Huashan Hospital, Fudan University Shanghai 200040, China.
Renjie ChaiKey Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University Nanjing 210096, China.
ShanghaiTech University · CNSoutheast University · CNEye & ENT Hospital of Fudan University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Auditory hair cells are the mechanical sensors of sound waves in the inner ear, and the stereocilia, which are actin-rich protrusions of different heights on the apical surfaces of hair cells, are responsible for the transduction of sound waves into electrical signals. As a crucial actin-binding and bundling protein, espin is able to cross-link actin filaments and is therefore necessary for stereocilia morphogenesis. Using advanced super-resolution stimulated emission depletion microscopy, we imaged espin expression at the sub-diffraction limit along the whole length of the stereocilia in outer hair cells and inner hair cells in order to better understand espin's function in the development of stereocilia.

Indexed as

Espinstereociliasuper-resolution imaging

Identifiers

PMID32051742
PMCPMC7013225
OpenAlexW3008295843

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.