ArticleEuropean heart journal2020
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel.
3 registry-linked trialsAbstract readConsensus Statement
In one paragraph
Article in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 733 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
733citing papers in PubMed, 10 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Tirzepatide on Coronary Plaque Lipid Content and Myocardial Microvascular Function in Overweight and Obese People With Coronary Disease - The IDEAL-COR Study
PMID 30293770PMID 27295427PMID 30473097PMID 27633186PMID 35658024PMID 34170647PMID 20061546PMID 26685971PMID 26242984PMID 23288155PMID 21525448PMID 30291013other papers from this trial
Open the trial in the graphCombined Effects of Statins and Exercise on Physiological Health Markers and Quality of Life in Patients With Dyslipidaemia
PMID 31875915PMID 23199849PMID 23583255PMID 17329991PMID 38385748PMID 29204622PMID 29040646PMID 26331605PMID 22776869PMID 22653988PMID 22269104PMID 22102458other papers from this trial
Open the trial in the graphNCT07050134 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation
A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of DR10624 in Patients With Hypertriglyceridemia and Carotid Atherosclerotic Plaque
Who cites it
733 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Lipid-Lowering Efficacy and Adverse Events of CETP Inhibitor Combination Therapy: A Systematic Review and Network Meta-Analysis.Journal of cardiovascular pharmacology · 2026Pooled it
- National Heart Center/Saudi Heart Association 2025 Guidelines for Cardiovascular Diseases Prevention and Risk Assessment.Saudi medical journal · 2026Guideline
- Effects of Antiseizure Medications on Lipid Profile and Weight in Patients with Epilepsy: A Systematic Review with Meta-analysis.CNS drugs · 2025Pooled it
- The role of variables of aquatic training performed in the upright position in improving the lipid profile of adults: systematic review with meta-analysis and meta regression.Scientific reports · 2025Pooled it
- Cardiovascular Disease in the Context of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Comprehensive Narrative Review.International journal of molecular sciences · 2025Pooled it
- Efficacy and safety of variable-dose metformin as adjunctive therapy to insulin in adolescents with type 1 diabetes mellitus: a systematic review and network meta-analysis.BMC endocrine disorders · 2025Pooled it
- Cholesterol-lowering drug targets reduce risk of dementia: Mendelian randomization and meta-analyses of 1 million individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Tumor Extracellular Vesicles Aggravate Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Pooled it
- Pooled it
- The causal relationship between 179 lipid species and urolithiasis: a bidirectional and multivariable Mendelian randomization study combined with meta-analysis.Lipids in health and disease · 2025Pooled it
- Trial
- Machine Learning-Based Prediction of Comprehensive Lipid Response to Dietary Interventions in Overweight and Obese Women.Nutrients · 2026Trial
- Effect of 2 Weeks of Time-Restricted Eating on Innate Immunity and Systemic Inflammation in Patients With a History of Myocardial Infarction: A Randomized-Controlled Crossover Study.Journal of the American Heart Association · 2026Trial
- Cow's milk compared to oat drink and its implications for lipid profile- a pilot randomized controlled trial.Nutrition journal · 2026Trial
- Effects of aged black garlic (ABG10+Frontiers in nutrition · 2026Trial
- Trial
- Enhancement of Statin Effects on Lipid Lowering and Reduction of Cardiovascular Risk Score by (-)-Epicatechin in Proof-of-Concept Pilot Study.Clinical and translational science · 2025Trial
- A Phase I Study to Evaluate the Relative Bioavailability, Pharmacodynamics, and Safety of a Single Subcutaneous Injection of Recaticimab at Three Different Sites in Healthy Chinese Subjects.European journal of drug metabolism and pharmacokinetics · 2025Trial
- Anti-inflammatory agents in atherosclerosis-and a need for reform: Extraordinary claims require extraordinary evidence.Journal of internal medicine · 2026Review
- Interactions between minimal amount of exercise and low-density lipoprotein cholesterol on incident dementia after stroke.iScience · 2026Article
673 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Jan BorénDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
M John ChapmanEndocrinology-Metabolism Division, Pitié-Salpêtrière University Hospital, Sorbonne University, Paris, France.
Ronald M KraussDepartment of Atherosclerosis Research, Children's Hospital Oakland Research Institute and UCSF, Oakland, CA 94609, USA.
Chris J PackardInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Jacob F BentzonDepartment of Clinical Medicine, Heart Diseases, Aarhus University, Aarhus, Denmark.
Christoph J BinderDepartment of Laboratory Medicine, Medical University of Vienna, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Mat J DaemenDepartment of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Linda L DemerDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Robert A HegeleDepartment of Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Stephen J NichollsMonash Cardiovascular Research Centre, Monash University, Melbourne, Australia.
Børge G NordestgaardDepartment of Clinical Biochemistry, The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, Denmark.
Gerald F WattsSchool of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Australia.
Eric BruckertINSERM UMRS1166, Department of Endocrinology-Metabolism, ICAN - Institute of CardioMetabolism and Nutrition, AP-HP, Hopital de la Pitie, Paris, France.
Sergio FazioDepartments of Medicine, Physiology and Pharmacology, Knight Cardiovascular Institute, Center of Preventive Cardiology, Oregon Health & Science University, Portland, OR, USA.
Brian A FerenceCentre for Naturally Randomized Trials, University of Cambridge, Cambridge, UK.
Ian GrahamTrinity College Dublin, Dublin, Ireland.
Jay D HortonDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ulf LandmesserDepartment of Cardiology, Charité - University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany.
Ulrich LaufsKlinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstraße 20, Leipzig, Germany.
Luis MasanaResearch Unit of Lipids and Atherosclerosis, IISPV, CIBERDEM, University Rovira i Virgili, C. Sant Llorenç 21, Reus 43201, Spain.
Gerard PasterkampLaboratory of Clinical Chemistry, University Medical Center Utrecht, Utrecht, The Netherlands.
Frederick J RaalCarbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Kausik K RayDepartment of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, Imperial College London, London, UK.
Heribert SchunkertDeutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Faculty of Medicine, Technische Universität München, Lazarettstr, Munich, Germany.
Marja-Riitta TaskinenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Bart van de SluisDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Olov WiklundDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
Lale TokgozogluDepartment of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Alberico L CatapanoDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, and IRCCS MultiMedica, Milan, Italy.
Henry N GinsbergDepartment of Medicine, Irving Institute for Clinical and Translational Research, Columbia University, New York, NY, USA.
Funding
TRANSCRIPTIONAL REGULATION OF LDL RECEPTOR PROMOTERP01HL020948 · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · 1985 to 2005
$28.1MNHLBI NIH HHS P01 HL020948
Abstract
PubMed holds no abstract for this paper.
Indexed as
AtherosclerosisCardiovascular DiseasesCholesterol, LDLConsensusHumansCholesterol, LDL
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.