Evidence map›Paper›PMID 32052855›Full record

ReviewCardiology journal2021

Local fluid dynamics in patients with bifurcated coronary lesions undergoing percutaneous coronary interventions.

Lorenzo Genuardi, Yiannis S Chatzizisis, Claudio Chiastra, Gregory Sgueglia, Habib Samady, Ghassan S Kassab, Francesco Migliavacca, Carlo Trani, Francesco Burzotta

Abstract readReview
In one paragraph

Review in Cardiology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Mechanistic Insights Into How Rewiring and Bifurcation Angle Affect DK-Crush Stent Deployment.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Advancements in Coronary Bifurcation Stenting Techniques: Insights From Computational and Bench Testing Studies.International journal for numerical methods in biomedical engineering · 2025
    Review
  8. Article
  9. Hepatic artery stenting with Viabahn.CVIR endovascular · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Wall shear stress and its role in atherosclerosis.Frontiers in cardiovascular medicine · 2023
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Percutaneous coronary intervention for bifurcation coronary lesions: the 15EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lorenzo GenuardiInstitute of Cardiology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy, L.go A. Gemelli, 8, 00168 Rome, Italy.
Yiannis S ChatzizisisCardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA., Omaha, United States.
Claudio ChiastraLaboratory of Biological Structure Mechanics (LaBS), Chemistry, Materials and Chemical engineering "Giulio Natta" Department, Politecnico di Milano, Milan, Italy, Milan, Italy.
Gregory SguegliaDivision of Cardiology, Sant'Eugenio Hospital, Rome, Italy, Rome, Italy.
Habib SamadyAndreas Gruentzig Cardiovascular Center, Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA, Atlanta, United States.
Ghassan S KassabCalifornia Medical Innovations Institute, San Diego, CA, USA, San Diego, United States.
Francesco MigliavaccaLaboratory of Biological Structure Mechanics (LaBS), Chemistry, Materials and Chemical engineering "Giulio Natta" Department, Politecnico di Milano, Milan, Italy, Milan, Italy.
Carlo TraniInstitute of Cardiology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy, L.go A. Gemelli, 8, 00168 Rome, Italy.
Francesco BurzottaInstitute of Cardiology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy, L.go A. Gemelli, 8, 00168 Rome, Italy. francescoburzotta@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the coronary arteries are uniformly exposed to systemic cardiovascular risk factors, atherosclerosis development has a non-random distribution, which follows the local mechanical stresses including flow-related hemodynamic forces. Among these, wall shear stress plays an essential role and it represents the major flow-related factor affecting the distribution of atherosclerosis in coronary bifurcations. Furthermore, an emerging body of evidence suggests that hemodynamic factors such as low and oscillating wall shear stress may facilitate the development of in-stent restenosis and stent thrombosis after successful drug-eluting stent implantation. Drug-eluting stent implantation represents the gold standard for bifurcation interventions. In this specific setting of interventions on bifurcated lesions, the impact of fluid dynamics is expected to play a major role and constitutes substantial opportunity for future technical improvement. In the present review, available data is summarized regarding the role of local fluid dynamics in the clinical outcome of patients with bifurcated lesions.

Indexed as

Coronary Artery DiseaseDrug-Eluting StentsPercutaneous Coronary InterventionCoronary RestenosisHumansHydrodynamicsStentsTreatment Outcomebifurcation stentingcoronary bifurcation lesionsfluid dynamicsin-stent restenosis and thrombosispercutaneous coronary interventionwall shear stress

Identifiers

PMID32052855
PMCPMC8078952

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.