Evidence map›Paper›PMID 32056010›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020

Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and clinical practice guidelines - part 2: honey, herbal compounds, saliva stimulants, probiotics, and miscellaneous agents.

Noam Yarom, Allan Hovan, Paolo Bossi, Anura Ariyawardana, Siri Beier Jensen, Margherita Gobbo, Hanan Saca-Hazboun, Abhishek Kandwal, Alessandra Majorana, Giulia Ottaviani and 13 more

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05664906 (Evaluating Efficacy and Safety of Chinese Medicine Oral Rinse in Treating and Preventing Irradiated Oral Mucositis in Head-and-Neck Cancer Patients - a Pilot Trial), which is not on this map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05664906 phase1 / phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

Evaluating Efficacy and Safety of Chinese Medicine Oral Rinse in Treating and Preventing Irradiated Oral Mucositis in Head-and-Neck Cancer Patients - a Pilot Trial

TypeinterventionalSponsorChinese University of Hong KongRan2023 to 2024Enrolled40ConditionsHead and Neck Neoplasms, Oral Mucositis (Ulcerative) Due to Radiation, Chinese Medicine Oral RinseArmsChinese Medicine Oral Rinse Formula-I (CMORF-I), Standard Care, Placebo
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Guideline
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Effects of Clarified Açaí Supplementation and Photobiomodulation on the Parotid Glands of Rats Submitted to Chemotherapy.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
    Article
  10. Review
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  15. Evaluation of A. actinomycetemcomitans and P. gingivalis from the mouth of patients irradiated in the head and neck region: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 16 institutions in 9 countries.

Noam YaromOral Medicine Unit, Sheba Medical Center, Tel Hashomer, Israel. Noam.yarom@sheba.health.gov.il.ORCID http://orcid.org/0000-0001-9771-7857
Allan HovanBritish Columbia Cancer-Vancouver Centre, Vancouver, Canada.
Paolo BossiDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health - Medical Oncology, University of Brescia, Spedali Civili, Brescia, Italy.
Anura AriyawardanaCollege of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia.
Siri Beier JensenDepartment of Dentistry and Oral Health, Faculty of Health, Aarhus University, Aarhus, Denmark.
Margherita GobboDivision of Oral Medicine and Pathology, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Hanan Saca-HazbounAl-Maha Cancer Foundation, Bethlehem, Palestine.
Abhishek KandwalSwami Rama Himayalan University Cancer research institute, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.
Alessandra MajoranaDental School University of Brescia Radiological, Department of Medical and Surgical Specialties, Science and Public Health, Brescia, Italy.
Giulia OttavianiDivision of Oral Medicine and Pathology, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Monica PenteneroDepartment of Oncology, Oral Medicine and Oral Oncology Unit, University of Turin, Turin, Italy.
Narmin Mohammed NasrSpecial Needs Dentistry, Dental Services, Ministry of Health, Muscat, Oman.
Tanya RouleauDental Oncology Program, Health Sciences North, North East Cancer Center, Sudbury, ON, Canada.
Anna Skripnik LucasMedical Oncology Service, Department of Medicine, NYU Langone Perlmutter Cancer Center, New York, NY, USA.
Nathaniel Simon TreisterDivision of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.
Eyal ZurCompounding Solutions, Tel-Mond, Israel.
Vinisha RannaThe Mount Sinai Hospital Department of Oral and Maxillofacial Surgery New York 10029, NY, USA.
Anusha VaddiUniversity of Rochester Medical Center Oral Medicine, Eastman Institute for Oral Health Rochester, New York, USA.
Andrei BaraschDental Clinics, Cambridge Health Alliance, Cambridge, MA, USA.
Rajesh V LallaDivision of Oral and Maxillofacial Diagnostic Sciences, UConn School of Dental Medicine, UConn Health, Farmington, CT, USA.
Karis Kin Fong ChengNational University of Singapore Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine , Singapore, Singapore.
Sharon EladUniversity of Rochester Medical Center Oral Medicine, Eastman Institute for Oral Health Rochester, New York, USA.
Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO)
University of Brescia · ITUniversity of Rochester Medical Center · USUniversity of Trieste · ITAarhus University · DKBrigham and Women's Hospital · USCambridge Health Alliance · USHealth Sciences North · CAMinistry of Health · OMMount Sinai Hospital · USNational University of Singapore · SGNYU Langone’s Laura and Isaac Perlmutter Cancer CenterQueensland Health · AUSwami Rama Himalayan University · INTel Aviv University · ILUConn Health · USUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo update the clinical practice guidelines for the management of oral mucositis (OM) that were developed by the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). This part focuses on honey, herbal compounds, saliva stimulants, probiotics, and miscellaneous agents.

methodsA systematic review was conducted by the Mucositis Study Group of MASCC/ISOO. The body of evidence for each intervention, in each clinical setting, was assigned an evidence level. The findings were added to the database used to develop the 2014 MASCC/ISOO clinical practice guidelines. Based on the evidence level, one of the following guidelines were determined: Recommendation, Suggestion, No Guideline Possible.

resultsA total of 78 papers were identified within the scope of this section, of which 49 were included in this review and merged with nine publications that were reported in the previous guidelines update. A new Suggestion was made for honey (combined topical and systemic delivery) for the prevention of OM in head and neck cancer patients receiving radiotherapy with or without chemotherapy. A new Suggestion clarified that chewing gum is not effective for the prevention of OM in pediatric patients with hematological or solid cancer treated with chemotherapy. No guideline was possible for other interventions.

conclusionsNumerous natural products and herbal remedies were studied for the management of OM. Of the agents reviewed in this systematic review, a guideline in favor was made for honey (combined topical and systemic), while a guideline against was made for chewing gum. Additional research is warranted to clarify the potential of other interventions.

Indexed as

HoneyPlants, MedicinalAntineoplastic AgentsCentral Nervous System StimulantsChewing GumHead and Neck NeoplasmsHumansMucositisProbioticsSalivaStomatitisAntineoplastic AgentsCentral Nervous System StimulantsChewing GumCancerComplementaryHerbalManagementNaturalOral mucositisTraditional

Identifiers

PMID32056010
OpenAlexW3006375128

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.