Evidence map›Paper›PMID 32061676›Full record

ReviewReproductive toxicology (Elmsford, N.Y.)2020

Review of the environmental prenatal exposome and its relationship to maternal and fetal health.

Julia E Rager, Jacqueline Bangma, Celeste Carberry, Alex Chao, Jarod Grossman, Kun Lu, Tracy A Manuck, Jon R Sobus, John Szilagyi, Rebecca C Fry

Abstract readReview
In one paragraph

Review in Reproductive toxicology (Elmsford, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia E RagerDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; The Institute for Environmental Health Solutions, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Toxicology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: jrager@unc.edu.
Jacqueline BangmaDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Celeste CarberryDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alex ChaoOak Ridge Institute for Science and Education (ORISE) Participant, Research Triangle Park, NC, USA.
Jarod GrossmanAgilent Technologies, Santa Clara, CA, USA.
Kun LuDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Toxicology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tracy A ManuckThe Institute for Environmental Health Solutions, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jon R SobusU.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Research Triangle Park, NC, USA.
John SzilagyiDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Rebecca C FryDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; The Institute for Environmental Health Solutions, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Toxicology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

STOCHASTIC ANALYSIS OF FLOW AND TRANSPORT PHENOMENAP42ES005948 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA · 1992 to 2017
$45.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
The Pharmacoepigenomics of Recurrent Preterm Birth in Non-Hispanic Black WomenR01MD011609 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MANUCK, TRACY A. · 2017 to 2021
$3.8M
Patient-oriented research and mentoring in preterm birth toxicogenomicsK24ES031131 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TRACY A. MANUCK · 2020 to 2026
$1.0M
NIEHS NIH HHS K24 ES031131NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P42 ES005948NIEHS NIH HHS T32 ES007126NIMHD NIH HHS R01 MD011609
6 · The paper itself

Abstract

Environmental chemicals comprise a major portion of the human exposome, with some shown to impact the health of susceptible populations, including pregnant women and developing fetuses. The placenta and cord blood serve as important biological windows into the maternal and fetal environments. In this article we review how environmental chemicals (defined here to include man-made chemicals [e.g., flame retardants, pesticides/herbicides, per- and polyfluoroalkyl substances], toxins, metals, and other xenobiotic compounds) contribute to the prenatal exposome and highlight future directions to advance this research field. Our findings from a survey of recent literature indicate the need to better understand the breadth of environmental chemicals that reach the placenta and cord blood, as well as the linkages between prenatal exposures, mechanisms of toxicity, and subsequent health outcomes. Research efforts tailored towards addressing these needs will provide a more comprehensive understanding of how environmental chemicals impact maternal and fetal health.

Indexed as

ExposomeFetal DevelopmentMaternal ExposureMaternal-Fetal ExchangeMaternal HealthAnimalsEnvironmental PollutantsFemaleFetal BloodHumansPlacentaPregnancyEnvironmental PollutantsDevelopmental toxicityEnvironmentExposomeFetusPregnancy

Identifiers

PMID32061676
PMCPMC7442624

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.