Evidence map›Paper›PMID 32061755›Full record

ArticleCancer letters2020

Oncoprotein GT198 vaccination delays tumor growth in MMTV-PyMT mice.

Bhagelu R Achyut, Hao Zhang, Kartik Angara, Nahid F Mivechi, Ali S Arbab, Lan Ko

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Decoding cancer and herbal renaissance.Longhua Chinese medicine · 2022
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Bhagelu R AchyutGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Hao ZhangDepartment of General Surgery, The First of Affiliated Hospital of Jinan University, And Institute of Precision Cancer Medicine and Pathology, Jinan University Medical College, Guangzhou, Guangdong, China; Research Center of Translational Medicine, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China. Electronic address: haozhang@jnu.edu.cn.
Kartik AngaraGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Nahid F MivechiGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Radiation Oncology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Ali S ArbabGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Lan KoGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: lan-ko@outlook.com.
Augusta University · USShantou University · CN

Funding

Role of heat shock transcription factor HSF1 in tumoroginesisR01CA062130 · NCI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI MIVECHI, NAHID F, MOSKOFIDIS, DIMITRIOS · 1996 to 2025
$9.0M
Role of heat shock factors (Hsfs) in tumorigenesisR01CA132640 · NCI · AUGUSTA UNIVERSITY · PI MIVECHI, NAHID F · 2008 to 2018
$2.7M
Understanding Mechanisms of Resistance to Anti-angiogenic TreatmentsR01CA160216 · NCI · HENRY FORD HEALTH SYSTEM · PI ARBAB, ALI SYED · 2012 to 2016
$1.8M
In vivo detection of involvement of endogenous BM progenitor cells in gliomaR01CA172048 · NCI · HENRY FORD HEALTH SYSTEM · PI ARBAB, ALI SYED · 2012 to 2014
$894k
NCI NIH HHS R01 CA062130NCI NIH HHS R01 CA132640NCI NIH HHS R01 CA160216NCI NIH HHS R01 CA172048
6 · The paper itself

Abstract

Targeting early lesion in breast cancer is more therapeutically effective. We have previously identified an oncoprotein GT198 (PSMC3IP) in human breast cancer. Here we investigated GT198 in MMTV-PyMT mouse mammary gland tumors and found that GT198 is a shared early lesion in both species. Similar to human breast cancer even before a tumor appears, cytoplasmic GT198 is overexpressed in mouse tumor stroma including pericyte stem cells, descendent adipocytes, fibroblasts, and myoepithelial cells. Using recombinant GT198 protein as an antigen, we vaccinated MMTV-PyMT mice and found that the GT198 vaccine delayed mouse tumor growth and reduced lung metastasis. The antitumor effects were linearly correlated with vaccinated mouse serum titers of GT198 antibody, which recognized cell surface GT198 protein on viable tumor cells confirmed by FACS. Furthermore, GT198

Indexed as

AnimalsAntigens, Polyomavirus TransformingCancer VaccinesFemaleHumansLung NeoplasmsMammary Neoplasms, ExperimentalMiceMice, Inbred StrainsNuclear ProteinsTrans-ActivatorsVaccinationAntigens, Polyomavirus TransformingCancer VaccinesNuclear ProteinsPSMC3IP protein, humanTrans-ActivatorsBreast cancerCancer vaccineImmunotherapyPericytesTumor-associated antigenTumor stroma

Identifiers

PMID32061755
PMCPMC7067666
OpenAlexW3006426845

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.