SynthesisJournal of atherosclerosis and thrombosis2020
The Relationship of Coronary Artery Calcium and Clinical Coronary Artery Disease with Cognitive Function: A Systematic Review and Meta-Analysis.
Synthesis in Journal of atherosclerosis and thrombosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Coronary Artery Calcium Progression and Cognitive Function in Midlife-The Coronary Artery Risk Development in Young Adults (CARDIA) Study.Circulation. Population health and outcomes · 2026Article
- Cognition and coronary events: A narrative overview of neurocognitive impairment in ACS patients.American heart journal plus : cardiology research and practice · 2025Review
- Genomic Characterisation of the Relationship and Causal Links Between Vascular Calcification, Alzheimer's Disease, and Cognitive Traits.Biomedicines · 2025Article
- Cardiovascular disease attenuates the protective effect of folate on global cognitive function in an elderly population: a cross-sectional study.Scientific reports · 2025Article
- Relationship Between Depression and Decreased Activity Level and Cognitive Impairment in Patients with Diabetes Mellitus Type 2 and/or Atrial Fibrillation.Journal of clinical medicine · 2025Article
- Walking reduces the risk of dementia in patients with Parkinson's disease: a longitudinal follow-up study.Therapeutic advances in neurological disorders · 2025Article
- P-Wave Duration Is Associated With Aging Patterns in Structural Brain Networks.Journal of the American Heart Association · 2024Article
- Atrial Fibrillation and Dementia: Pathophysiological Mechanisms and Clinical Implications.Biomolecules · 2024Review
- Effect of different coronary artery revascularization procedures on cognition: A systematic review.Heliyon · 2023Article
- Using Machine Learning to Predict Cognitive Impairment Among Middle-Aged and Older Chinese: A Longitudinal Study.International journal of public health · 2023Article
- Abdominal aortic calcification on lateral spine images captured during bone density testing and late-life dementia risk in older women: A prospective cohort study.The Lancet regional health. Western Pacific · 2022Article
- Review
- The interaction and pathogenesis between cognitive impairment and common cardiovascular diseases in the elderly.Therapeutic advances in chronic disease · 2022Review
- Random-Forest-Algorithm-Based Applications of the Basic Characteristics and Serum and Imaging Biomarkers to Diagnose Mild Cognitive Impairment.Current Alzheimer research · 2022Article
- Coronary Artery Calcium: A Risk Factor for Brain Aging?Circulation. Cardiovascular imaging · 2021Article
- Coronary Artery Calcium and Cognitive Function in Dutch Adults: Cross-Sectional Results of the Population-Based ImaLife Study.Journal of the American Heart Association · 2021Article
- 20-Year trend of high prevalence of zero coronary artery calcium in beach cities of Southern California: A blue zone?American journal of preventive cardiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimCoronary artery disease (CAD) and cognitive impairment are common in the elderly, with evidence for shared risk factors and pathophysiological processes. The coronary artery calcium (CAC) score is a marker of subclinical CAD, which may allow early detection of individuals prone to cognitive decline. Prior studies on associations of CAC and clinical CAD with cognitive impairment had discrepant results. This systematic review aims to evaluate the association of (sub)clinical CAD with cognitive function, cognitive decline, and diagnosis of mild cognitive impairment (MCI) or dementia.
methodsA systematic search was conducted in MEDLINE, Embase, and Web of Science until February 2019, supplemented with citations tracking. Two reviewers independently screened studies and extracted information including odds ratios (ORs) and hazard ratios (HRs).
resultsForty-six studies, 10 on CAC and 36 on clinical CAD, comprising 1,248,908 participants were included in the systematic review. Studies about associations of (sub)clinical CAD with cognitive function and cognitive decline had heterogeneous methodology and inconsistent findings. Two population-based studies investigated the association between CAC and risk of dementia over 6-12.2 years using different CAC scoring methods. Both found a tendency toward higher risk of dementia as CAC severity increased. Meta-analysis in 15 studies (663,250 individuals) showed an association between CAD and MCI/dementia (pooled OR 1.32, 95%CI 1.17-1.48) with substantial heterogeneity (I
conclusionsLimited evidence suggests the CAC score is associated with risk of dementia. In clinical CAD, risk of MCI and dementia is increased by 50%, as supported by stronger evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.