Evidence map›Paper›PMID 32062672›Full record

Trial reportBlood2020

Baseline TP53 mutations in adults with SCD developing myeloid malignancy following hematopoietic cell transplantation.

Jack Y Ghannam, Xin Xu, Irina Maric, Laura Dillon, Yuesheng Li, Matthew M Hsieh, Christopher S Hourigan, Courtney D Fitzhugh

Open access · bronzeAbstract readClinical TrialLetter
In one paragraph

Trial report in Blood, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Clonal hematopoiesis in sickle cell disease.The Journal of clinical investigation · 2022
    Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Ex vivo modification of hematopoietic stem and progenitor cells for gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Myeloproliferative Neoplasms: Challenging Dogma.Journal of clinical medicine · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jack Y GhannamLaboratory of Myeloid Malignancies, Hematology Branch, and.
Xin XuCellular and Molecular Therapeutics Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Irina MaricDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD; and.
Laura DillonLaboratory of Myeloid Malignancies, Hematology Branch, and.
Yuesheng LiDNA Sequencing and Genomics Core, Office of the Scientific Director, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Matthew M HsiehCellular and Molecular Therapeutics Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Christopher S HouriganLaboratory of Myeloid Malignancies, Hematology Branch, and.
Courtney D FitzhughCellular and Molecular Therapeutics Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
National Institutes of Health · USNational Heart Lung and Blood Institute · USNational Institutes of Health Clinical Center · US

Funding

Detection, prevention and treatment of acute myeloid leukemia (AML) relapse.ZIAHL006163 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI HOURIGAN, CHRISTOPHER · 2013 to 2023
$21.0M
Nonmyeloablative haploidentical peripheral blood stem cell transplantation in congenital anemiasZIAHL006211 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI FITZHUGH, COURTNEY · 2016 to 2025
$19.4M
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAnemia, Sickle CellHematopoietic Stem Cell TransplantationHumansLeukemia, Myeloid, AcuteMyelodysplastic SyndromesPoint MutationTumor Suppressor Protein p53TP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID32062672
PMCPMC7118814
OpenAlexW3006523030

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.