ArticleScience advances2019
Constraint and trade-offs regulate energy expenditure during childhood.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Dietary Transitions and Health Outcomes in Four Populations - Systematic Review.Frontiers in nutrition · 2022Pooled it
- Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026Review
- Menopause Averted a Midlife Energetic Crisis With Help From Older Dependent Children and Parents: A Simulation Study.American journal of biological anthropology · 2026Article
- Longitudinal and cross-sectional evidence that daily resting and activity energy expenditures are independent in humans.The Journal of physiology · 2026Article
- Navigating Practical, Political, and Ethical Challenges of Long-Term Human Biology Field Research: The Shuar Health and Life History Project.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- The Shuar Health and Life History Project: Overview at 20 Years and Introduction to the Special Issue.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Association of Intestinal Amino Acid Absorption with the Uptake of Lactulose and Rhamnose in Adults with Environmental Enteropathy.The American journal of tropical medicine and hygiene · 2025Article
- Energy expenditure and obesity across the economic spectrum.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Relationship Between Type of Delivery and Growth Trajectory in the First Year of Life: The Araraquara Cohort Study.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Resting metabolic rate and energy efficiency in response to an intensive 84-day combat-swimmer training in the German Armed Forces.European journal of applied physiology · 2025Article
- Chronic Stress and Severe Water Insecurity During the Historic 2022 Drought in Northern Kenya Were Associated With Inflammation Among Daasanach Seminomadic Pastoralists.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Sex-specific association between maternal childhood adversities and offspring's weight gain in a Brazilian cohort.Scientific reports · 2025Article
- Oxidative Stress in Children and Adolescents: Insights Into Human Biology.American journal of human biology : the official journal of the Human Biology Council · 2025Review
- Contemporary small-scale subsistence populations offer unique insights into human musculoskeletal health and aging.Science advances · 2024Review
- Short-term dynamics of linear growth among Peruvian infants in the first year of life in a population with linear growth faltering.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- [Energy metabolism of the immune system : Consequences in chronic inflammation].Zeitschrift fur Rheumatologie · 2023Review
- Free living total energy expenditure in young South Indian children at risk of environmental enteric dysfunction and its relation to faltered linear growth.European journal of clinical nutrition · 2023Article
- Perspective: Is the Response of Human Energy Expenditure to Increased Physical Activity Additive or Constrained?Advances in nutrition (Bethesda, Md.) · 2023Article
- The aorta in humans and African great apes, and cardiac output and metabolic levels in human evolution.Scientific reports · 2023Article
- Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure.Nature metabolism · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children's metabolic energy expenditure is central to evolutionary and epidemiological frameworks for understanding variation in human phenotype and health. Nonetheless, the impact of a physically active lifestyle and heavy burden of infectious disease on child metabolism remains unclear. Using energetic, activity, and biomarker measures, we show that Shuar forager-horticulturalist children of Amazonian Ecuador are ~25% more physically active and, in association with immune activity, have ~20% greater resting energy expenditure than children from industrial populations. Despite these differences, Shuar children's total daily energy expenditure, measured using doubly labeled water, is indistinguishable from industrialized counterparts. Trade-offs in energy allocation between competing physiological tasks, within a constrained energy budget, appear to shape childhood phenotypic variation (e.g., patterns of growth). These trade-offs may contribute to the lifetime obesity and metabolic health disparities that emerge during rapid economic development.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.