ReviewBritish journal of haematology2020
Pregnancy in sickle cell trait: what we do and don't know.
Review in British journal of haematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Phenome- and laboratory-wide meta-analyses of sickle cell trait reveal multi-system disease associations.American journal of human genetics · 2026Pooled it
- Clinical Implications of Sickle Cell Thalassemia on Pregnancy Outcomes: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Characterizing pregnancy outcomes in a humanized mouse model of sickle cell disease.British journal of haematology · 2025Article
- Strategies for reducing child mortality due to sickle cell disease in Uganda: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Effects of sickle trait on maternal and perinatal outcomes among pregnant women.Blood vessels, thrombosis & hemostasis · 2025Article
- Adverse clinical outcomes associated with sickle cell trait at high altitude.Haematologica · 2025Article
- Assessing the Impact of Hematological Changes in Pregnancy on Maternal and Fetal Death: A Narrative Review.Cureus · 2024Review
- Society for Maternal-Fetal Medicine Consult Series #68: Sickle cell disease in pregnancy.American journal of obstetrics and gynecology · 2024Article
- Red Blood Cell Exchange as a Valid Therapeutic Approach for Pregnancy Management in Sickle Cell Disease: Three Explicative Cases and Systematic Review of Literature.Journal of clinical medicine · 2023Review
- Co-Occurrence of G6PD Deficiency and SCT among Pregnant Women Exposed to Infectious Diseases.Journal of clinical medicine · 2023Article
- Association of sickle cell trait with adverse pregnancy outcomes in a population-based cohort.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Management of the Sickle Cell Trait: An Opinion by Expert Panel Members.Journal of clinical medicine · 2023Review
- Adverse Pregnancy Outcomes in Sickle Cell Trait: a Prospective Cohort Study Evaluating Clinical and Haematological Parameters in Postpartum Mothers and Newborns.Mediterranean journal of hematology and infectious diseases · 2023Article
- Evaluation of Stillbirth Among Pregnant People With Sickle Cell Trait.JAMA network open · 2021Article
- Sickle Cell Trait Presenting as Unilateral Proliferative Retinopathy and Macular Thinning in a Pregnant Woman.Case reports in ophthalmological medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sickle cell trait (SCT) is the carrier state for sickle cell disease that results from the HBB rs334 missense mutation (p.Glu6Val) in the β-globin chain of haemoglobin. While not associated with any impact on life expectancy, it has been established that SCT is associated with an increased risk of both venous thromboembolism (and in particular, pulmonary embolism) and chronic kidney disease. It is largely unknown what short- or long-term effect, if any, pregnancy has upon the risk or outcomes of these disorders. In addition, SCT has been linked with various adverse outcomes in pregnancy, ranging from maternal complications such as elevated risk of bacteriuria to potentially life-threatening entities such as pre-eclampsia and prematurity. In these scenarios also, no clear association with SCT has been established. Given the high worldwide prevalence of SCT, further studies addressing these issues are warranted.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.