ReviewJournal of materials chemistry. B2020
Substituted hydroxyapatite coatings of bone implants.
Review in Journal of materials chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
100 citing papers in PubMed.
- Metal-Substituted Hydroxyapatite Nanoparticles as Antimicrobial and Osteogenic Biomaterials for Hard-Tissue Applications.Materials (Basel, Switzerland) · 2026Review
- Biomedical potential of bovine-derived hydroxyapatite: synthesis strategies, characterization and applications.RSC advances · 2026Review
- Applicability of Whole Blood Monocyte Activation Test for Endotoxin Activity Assessment in Hydroxyapatite-Based Ceramics.Bioengineering (Basel, Switzerland) · 2026Article
- Biocompatible Thin Films Deposited by Laser Techniques.Materials (Basel, Switzerland) · 2026Review
- In silico study of a bilayer titanium dental implant with a porous titanium and hydroxyapatite composite outer layer for enhanced osseointegration.Scientific reports · 2026Article
- Dual pH-Responsive Calcium Phosphate Nanoparticles Conjugated with Folate by CuAAC Click Chemistry for Targeted Gemcitabine Delivery to Cancer Cells.ACS applied bio materials · 2026Article
- Antibacterial performance of biomimetic hydroxyapatite-functionalized titanium surfaces againstFrontiers in oral health · 2026Article
- Osseointegration of implant with various surface treatments.Bioinformation · 2026Article
- Ultrasonic irradiation in the synthesis of nanohydroxyapatite: a chemically friendly technique for improving hemocompatibility and antibiofilm applications.Beilstein journal of nanotechnology · 2026Article
- Bone matrix-mimetic multi-ion doped hydroxyapatite nanorod arrays for enhanced immuno-osteogenesis and prevention of aseptic loosening.Bioactive materials · 2026Article
- Strategies to Enhance Yield of Wet-Synthesized Hydroxyapatite Nanocrystals and Consequences for Drug-Release Kinetics.Materials (Basel, Switzerland) · 2025Article
- Role of noble and rare earth metals in bioactive materials for medical applications in tissue engineering.RSC advances · 2025Review
- 3D printed bone nails loaded with ceftriaxone sodium for localized drug delivery.Scientific reports · 2025Article
- Advances in 3D-printed scaffold technologies for bone defect repair: materials, biomechanics, and clinical prospects.Biomedical engineering online · 2025Review
- Functionalized zeolite regulates bone metabolic microenvironment.Materials today. Bio · 2025Review
- Evolution of Metals and Alloys in Orthopedics with Their Relevance in Osteoporosis.Indian journal of orthopaedics · 2025Article
- Functional hydrogel empowering 3D printing titanium alloys.Materials today. Bio · 2025Review
- Oyster Shell Powder/PCL Composite Scaffolds Loaded with Psoralen Nanospheres Promote Large Bone Defect Repair.ACS omega · 2025Article
- Advanced surface modification techniques for titanium implants: a review of osteogenic and antibacterial strategies.Frontiers in bioengineering and biotechnology · 2025Review
- Osteogenic effects of electrophoretically deposited Sr-doped calcium silicate coatings on titanium.Frontiers in bioengineering and biotechnology · 2025Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Surface modification of orthopedic and dental implants has been demonstrated to be an effective strategy to accelerate bone healing at early implantation times. Among the different alternatives, coating implants with a layer of hydroxyapatite (HAp) is one of the most used techniques, due to its excellent biocompatibility and osteoconductive behavior. The composition and crystalline structure of HAp allow for numerous ionic substitutions that provide added value, such as antibiotic properties or osteoinduction. In this article, we will review and critically analyze the most important advances in the field of substituted hydroxyapatite coatings. In recent years substituted HAp coatings have been deposited not only on orthopedic prostheses and dental implants, but also on macroporous scaffolds, thus expanding their applications towards bone regeneration therapies. Besides, the capability of substituted HAps to immobilize proteins and growth factors by non-covalent interactions has opened new possibilities for preparing hybrid coatings that foster bone healing processes. Finally, the most important in vivo outcomes will be discussed to understand the prospects of substituted HAp coatings from a clinical point of view.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.