Evidence map›Paper›PMID 32065236›Full record

SynthesisPhysical therapy2020

The Effect of Exercise on Cancer-Related Cognitive Impairment and Applications for Physical Therapy: Systematic Review of Randomized Controlled Trials.

Kristin L Campbell, Kendra Zadravec, Kelcey A Bland, Elizabeth Chesley, Florian Wolf, Michelle C Janelsins

2 registry-linked trialsAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Physical therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 99 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05180656 nacompletednot on this mapstarted 2021, after this paper: background citation

The Impact of a Remotely-Delivered Yoga Intervention on Cognitive Function in Breast Cancer Survivors: A Feasibility Study

TypeinterventionalSponsorUniversity of TorontoRan2021 to 2022Enrolled18ConditionsBreast Cancer, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage IIIArmsYoga Intervention
NCT07453173 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot, Single-Arm, Prospective Study Assessing Feasibility and Safety of a Supervised Progressive Resistance Training Program During Total NeoadjuvantTherapy (RAPIDO) Until Surgery in Locally Advanced Rectal Cancer

TypeinterventionalSponsorFundacion Arturo Lopez PerezRan2026 to 2027Enrolled15ConditionsLocally Advanced Rectal CancerArmsStrength training program
3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Prevalence and assessment tools of cancer-related cognitive impairment in lung cancer survivors: a systematic review and proportional meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  6. Pooled it
  7. Telerehabilitation as a Therapeutic Exercise Tool versus Face-to-Face Physiotherapy: A Systematic Review.International journal of environmental research and public health · 2023
    Pooled it
  8. Pooled it
  9. Guideline
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  12. The effect of 12 sessions of lymphatic massage and Pilates exercise on the executive functions of breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  19. Factors associated with perceived cognitive impairment in patients with advanced lung cancer: a cross-sectional analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Trial
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristin L CampbellDepartment of Physical Therapy, University of British Columbia 212-2177 Wesbrook Mall, Vancouver, British Columbia, Canada V7J 3K6.
Kendra ZadravecRehabilitation Sciences, University of British Colombia.
Kelcey A BlandMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.
Elizabeth ChesleyBiology, University of British Columbia.
Florian WolfInstitute for Cardiovascular Research and Sports Medicine, German Sport University, Cologne, Germany.
Michelle C JanelsinsSurgery, University of Rochester, Rochester, New York.

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Clinical and Translational Approaches to Cognitive Impairments in CancerDP2CA195765 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C · 2014 to 2014
$2.3M
NCI NIH HHS DP2 CA195765NCI NIH HHS UG1 CA189961
6 · The paper itself

Abstract

backgroundCancer-related cognitive impairment (CRCI), often called "chemo-brain" or "chemo-fog," is a common side effect among adults with cancer, which can persist well after treatment completion. Accumulating evidence demonstrates exercise can improve cognitive function in healthy older adults and adults with cognitive impairments, suggesting exercise may play a role in managing CRCI. PURPOSE: The purpose was to perform a systematic review of randomized controlled trials (RCTs) to understand the effect of exercise on CRCI. DATA SOURCES: Relevant literature was retrieved from CINAHL, Medline (Ovid), and EMBASE. STUDY SELECTION: Eligible articles were RCTs that prescribed aerobic, resistance, combined aerobic/resistance, or mind-body (eg, yoga or Qigong) exercise during or following cancer treatment and included cognitive function outcome measures. DATA EXTRACTION: Descriptive information and Cohen d effect sizes were directly extracted or calculated for included trials. DATA SYNTHESIS: Twenty-nine trials were included in the final analysis. A statistically significant effect of exercise on self-reported cognitive function, both during and postadjuvant treatment, was reported in 12 trials (41%) (Cohen d range: 0.24-1.14), most commonly using the EORTC QLQ-C30. Ten trials (34%) performed neuropsychological testing to evaluate cognitive function; however, only 3 trials in women with breast cancer reported a significant effect of exercise (Cohen d range: 0.41-1.47). LIMITATIONS: Few RCTs to date have evaluated the effect of exercise on CRCI as a primary outcome. Twenty-six trials (90%) in this review evaluated CRCI as secondary analyses.

conclusionsEvidence supporting exercise as a strategy to address CRCI is limited. Future research evaluating CRCI as a primary outcome, including self-reported and objective measures, is needed to confirm the possible role of exercise in preventing and managing cognitive impairments in adults with cancer.

Indexed as

ExerciseRandomized Controlled Trials as TopicAdultBreast NeoplasmsBreathing ExercisesCognitionCognitive DysfunctionFemaleHumansMaleNeoplasmsQigongResistance TrainingSelf ReportYoga

Identifiers

PMID32065236
PMCPMC8559683

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.