Evidence map›Paper›PMID 32067508›Full record

ReviewExpert opinion on drug discovery2020

Strategies for targeting the cardiac sarcomere: avenues for novel drug discovery.

Joshua B Holmes, Chang Yoon Doh, Ranganath Mamidi, Jiayang Li, Julian E Stelzer

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on drug discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joshua B HolmesDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0003-0288-2484
Chang Yoon DohDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-5071-4832
Ranganath MamidiDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0001-9168-9613
Jiayang LiDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0001-9271-3988
Julian E StelzerDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-6870-9054

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Computer modeling of myosin binding protein C and its effects on cardiac contractionR01HL146676 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI Kenneth S Campbell, Julian Stelzer · 2019 to 2026
$4.3M
Functional consequences of FHC mutations in cardiac MyBPCR01HL114770 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STELZER, JULIAN · 2013 to 2023
$4.3M
High resolution ultrasound for small animal imagingS10OD021635 · OD · CASE WESTERN RESERVE UNIVERSITY · PI STELZER, JULIAN · 2016 to 2016
$478k
NHLBI NIH HHS R01 HL114770NHLBI NIH HHS R01 HL146676NIGMS NIH HHS T32 GM007250NIH HHS S10 OD021635
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCardiovascular AgentsDrug DevelopmentDrug DiscoveryDrug Evaluation, PreclinicalHeart FailureHumansSarcomeresCardiovascular Agentsbiophysical measurementscross-bridge kineticsDrug discoveryheart failurein vivo functionsarcomere-based therapysolution-based chemistry

Identifiers

PMID32067508
PMCPMC7065952

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.