Evidence map›Paper›PMID 32068507›Full record

ArticleRadiology2020

Preparing Medical Imaging Data for Machine Learning.

Martin J Willemink, Wojciech A Koszek, Cailin Hardell, Jie Wu, Dominik Fleischmann, Hugh Harvey, Les R Folio, Ronald M Summers, Daniel L Rubin, Matthew P Lungren

Abstract read
In one paragraph

Article in Radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 387 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
387citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

387 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Guideline
  4. Pooled it
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  12. Article
  13. Review
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  15. AI In Leukemia Diagnostics: Complementing the Pathologist's Role.International journal of laboratory hematology · 2026
    Review
  16. Article
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  18. Article
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327 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martin J WilleminkFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, S-072, Stanford, CA 94305-5105 (M.J.W., D.F., D.L.R., M.P.L.); Segmed, Menlo Park, Calif (M.J.W., W.A.K., C.H., J.W.); School of Engineering, Stanford University, Stanford, Calif (J.W.); Institute of Cognitive Neuroscience, University College London, London, England (H.H.); Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (L.R.F.); Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health, Clinical Center, Bethesda, Md (R.M.S.); Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, Calif (D.L.R.); and Stanford Center for Artificial Intelligence in Medicine and Imaging (AIMI), Stanford, Calif (M.P.L.).ORCID 0000-0002-6991-6557
Wojciech A KoszekFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, S-072, Stanford, CA 94305-5105 (M.J.W., D.F., D.L.R., M.P.L.); Segmed, Menlo Park, Calif (M.J.W., W.A.K., C.H., J.W.); School of Engineering, Stanford University, Stanford, Calif (J.W.); Institute of Cognitive Neuroscience, University College London, London, England (H.H.); Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (L.R.F.); Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health, Clinical Center, Bethesda, Md (R.M.S.); Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, Calif (D.L.R.); and Stanford Center for Artificial Intelligence in Medicine and Imaging (AIMI), Stanford, Calif (M.P.L.).ORCID 0000-0002-8949-8858
Cailin HardellFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, S-072, Stanford, CA 94305-5105 (M.J.W., D.F., D.L.R., M.P.L.); Segmed, Menlo Park, Calif (M.J.W., W.A.K., C.H., J.W.); School of Engineering, Stanford University, Stanford, Calif (J.W.); Institute of Cognitive Neuroscience, University College London, London, England (H.H.); Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (L.R.F.); Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health, Clinical Center, Bethesda, Md (R.M.S.); Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, Calif (D.L.R.); and Stanford Center for Artificial Intelligence in Medicine and Imaging (AIMI), Stanford, Calif (M.P.L.).
Jie WuFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, S-072, Stanford, CA 94305-5105 (M.J.W., D.F., D.L.R., M.P.L.); Segmed, Menlo Park, Calif (M.J.W., W.A.K., C.H., J.W.); School of Engineering, Stanford University, Stanford, Calif (J.W.); Institute of Cognitive Neuroscience, University College London, London, England (H.H.); Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (L.R.F.); Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health, Clinical Center, Bethesda, Md (R.M.S.); Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, Calif (D.L.R.); and Stanford Center for Artificial Intelligence in Medicine and Imaging (AIMI), Stanford, Calif (M.P.L.).ORCID 0000-0003-3564-9056
Dominik FleischmannFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, S-072, Stanford, CA 94305-5105 (M.J.W., D.F., D.L.R., M.P.L.); Segmed, Menlo Park, Calif (M.J.W., W.A.K., C.H., J.W.); School of Engineering, Stanford University, Stanford, Calif (J.W.); Institute of Cognitive Neuroscience, University College London, London, England (H.H.); Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (L.R.F.); Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health, Clinical Center, Bethesda, Md (R.M.S.); Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, Calif (D.L.R.); and Stanford Center for Artificial Intelligence in Medicine and Imaging (AIMI), Stanford, Calif (M.P.L.).ORCID 0000-0003-0715-0952
Hugh HarveyFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, S-072, Stanford, CA 94305-5105 (M.J.W., D.F., D.L.R., M.P.L.); Segmed, Menlo Park, Calif (M.J.W., W.A.K., C.H., J.W.); School of Engineering, Stanford University, Stanford, Calif (J.W.); Institute of Cognitive Neuroscience, University College London, London, England (H.H.); Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (L.R.F.); Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health, Clinical Center, Bethesda, Md (R.M.S.); Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, Calif (D.L.R.); and Stanford Center for Artificial Intelligence in Medicine and Imaging (AIMI), Stanford, Calif (M.P.L.).ORCID 0000-0003-4528-1312
Les R FolioFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, S-072, Stanford, CA 94305-5105 (M.J.W., D.F., D.L.R., M.P.L.); Segmed, Menlo Park, Calif (M.J.W., W.A.K., C.H., J.W.); School of Engineering, Stanford University, Stanford, Calif (J.W.); Institute of Cognitive Neuroscience, University College London, London, England (H.H.); Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (L.R.F.); Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health, Clinical Center, Bethesda, Md (R.M.S.); Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, Calif (D.L.R.); and Stanford Center for Artificial Intelligence in Medicine and Imaging (AIMI), Stanford, Calif (M.P.L.).
Ronald M SummersFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, S-072, Stanford, CA 94305-5105 (M.J.W., D.F., D.L.R., M.P.L.); Segmed, Menlo Park, Calif (M.J.W., W.A.K., C.H., J.W.); School of Engineering, Stanford University, Stanford, Calif (J.W.); Institute of Cognitive Neuroscience, University College London, London, England (H.H.); Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (L.R.F.); Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health, Clinical Center, Bethesda, Md (R.M.S.); Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, Calif (D.L.R.); and Stanford Center for Artificial Intelligence in Medicine and Imaging (AIMI), Stanford, Calif (M.P.L.).ORCID 0000-0001-8081-7376
Daniel L RubinFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, S-072, Stanford, CA 94305-5105 (M.J.W., D.F., D.L.R., M.P.L.); Segmed, Menlo Park, Calif (M.J.W., W.A.K., C.H., J.W.); School of Engineering, Stanford University, Stanford, Calif (J.W.); Institute of Cognitive Neuroscience, University College London, London, England (H.H.); Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (L.R.F.); Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health, Clinical Center, Bethesda, Md (R.M.S.); Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, Calif (D.L.R.); and Stanford Center for Artificial Intelligence in Medicine and Imaging (AIMI), Stanford, Calif (M.P.L.).
Matthew P LungrenFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, S-072, Stanford, CA 94305-5105 (M.J.W., D.F., D.L.R., M.P.L.); Segmed, Menlo Park, Calif (M.J.W., W.A.K., C.H., J.W.); School of Engineering, Stanford University, Stanford, Calif (J.W.); Institute of Cognitive Neuroscience, University College London, London, England (H.H.); Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (L.R.F.); Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health, Clinical Center, Bethesda, Md (R.M.S.); Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, Calif (D.L.R.); and Stanford Center for Artificial Intelligence in Medicine and Imaging (AIMI), Stanford, Calif (M.P.L.).ORCID 0000-0002-8591-5861

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Qualification and Deployment of Imaging Biomarkers of Cancer Treatment ResponseU01CA190214 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2015 to 2020
$3.1M
Computing, Optimizing, and Evaluating Quantitative Cancer Imaging BiomarkersU01CA187947 · NCI · STANFORD UNIVERSITY · PI NAPEL, SANDY A., RUBIN, DANIEL L · 2015 to 2019
$2.9M
Computerized Quantitative Imaging Assessment of Tumor BurdenU01CA142555 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2010 to 2014
$2.9M
Deep Learning for Pulmonary Embolism Imaging Decision Support: A Multi-institutional CollaborationR01LM012966 · NLM · STANFORD UNIVERSITY · PI SHAH, NIGAM H · 2018 to 2021
$1.4M
Distributed Learning of Deep Learning Models for Cancer ResearchU01CA242879 · NCI · STANFORD UNIVERSITY · PI KALPATHY-CRAMER, JAYASHREE, RUBIN, DANIEL L · 2019 to 2021
$1.2M
Computer Aided Detection for Radiologic ImagesZIACL040004 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2009 to 2025
$0k
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142NCI NIH HHS U01 CA142555NCI NIH HHS U01 CA187947NCI NIH HHS U01 CA190214NCI NIH HHS U01 CA242879NLM NIH HHS R01 LM012966
6 · The paper itself

Abstract

Artificial intelligence (AI) continues to garner substantial interest in medical imaging. The potential applications are vast and include the entirety of the medical imaging life cycle from image creation to diagnosis to outcome prediction. The chief obstacles to development and clinical implementation of AI algorithms include availability of sufficiently large, curated, and representative training data that includes expert labeling (eg, annotations). Current supervised AI methods require a curation process for data to optimally train, validate, and test algorithms. Currently, most research groups and industry have limited data access based on small sample sizes from small geographic areas. In addition, the preparation of data is a costly and time-intensive process, the results of which are algorithms with limited utility and poor generalization. In this article, the authors describe fundamental steps for preparing medical imaging data in AI algorithm development, explain current limitations to data curation, and explore new approaches to address the problem of data availability.

Indexed as

AlgorithmsData CollectionData ManagementDiagnostic ImagingMachine LearningHumans

Identifiers

PMID32068507
PMCPMC7104701

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.