Evidence map›Paper›PMID 32069073›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2020

Chronic stimulation induces adaptive potassium channel activity that restores calcium oscillations in pancreatic islets in vitro.

Nathan C Law, Isabella Marinelli, Richard Bertram, Kathryn L Corbin, Cara Schildmeyer, Craig S Nunemaker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nathan C LawDepartment of Biomedical Sciences Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio.
Isabella MarinelliBasque Center for Applied Mathematics, Bilbao, Basque Country, Spain.
Richard BertramDepartment of Mathematics and Programs in Neuroscience and Molecular Biophysics, Florida State University, Tallahassee, Florida.ORCID 0000-0001-8577-2592
Kathryn L CorbinDepartment of Biomedical Sciences Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio.
Cara SchildmeyerDepartment of Biomedical Sciences Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio.
Craig S NunemakerDepartment of Biomedical Sciences Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio.ORCID 0000-0003-2894-3388
Ohio University · USBasque Center for Applied Mathematics · ESFlorida State University · US

Funding

Reducing Glycolytic Activity to Restore Normal Islet Glucose Sensing in Early Type 2 DiabetesR15DK121247 · NIDDK · OHIO UNIVERSITY ATHENS · PI NUNEMAKER, CRAIG S · 2019 to 2019
$453k
NIDDK NIH HHS R15 DK121247
6 · The paper itself

Abstract

Insulin pulsatility is important to hepatic response in regulating blood glucose. Growing evidence suggests that insulin-secreting pancreatic β-cells can adapt to chronic disruptions of pulsatility to rescue this physiologically important behavior. We determined the time scale for adaptation and examined potential ion channels underlying it. We induced the adaptation both by chronic application of the ATP-sensitive K

Indexed as

Adaptation, PhysiologicalCalcium SignalingAnimalsCell MembraneCongenital HyperinsulinismHumansInsulin-Secreting CellsIslets of LangerhansKATP ChannelsMaleMiceModels, TheoreticalPotassium Channel BlockersPotassium ChannelsPotassium Channels, Inwardly RectifyingPotassium ChlorideKATP ChannelsKir2.1 channelPotassium Channel BlockersPotassium ChannelsPotassium Channels, Inwardly RectifyingPotassium ChlorideTolbutamidecongenital hyperinsulinemiaintracellular calciumisletsK(ATP)-channeloscillationspersistent hyperinsulinemic hypoglycemia of infancyPHHIpotassiumpulsatilitytolbutamideβ-cells

Identifiers

PMID32069073
PMCPMC7191410
OpenAlexW3006818680

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.