Evidence map›Paper›PMID 32071264›Full record

ArticlemBio2020

Plant Virus Genome Is Shaped by Specific Dinucleotide Restrictions That Influence Viral Infection.

Alfonso González de Prádena, Adrián Sánchez Jimenez, David San León, Peter Simmonds, Juan Antonio García, Adrián A Valli

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Construction of Attenuated Viruses by Changing the UpA Dinucleotide Frequency.Methods in molecular biology (Clifton, N.J.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Alfonso González de PrádenaCentro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Adrián Sánchez JimenezCentro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
David San LeónLeiden University Medical Center (LUMC), Leiden, The Netherlands.
Peter SimmondsNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Juan Antonio GarcíaCentro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain jagarcia@cnb.csic.es avalli@cnb.csic.es.ORCID 0000-0002-4861-9609
Adrián A ValliCentro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain jagarcia@cnb.csic.es avalli@cnb.csic.es.
Centro Nacional de Biotecnología · ESLeiden University Medical Center · NLUniversity of Oxford · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

The presence of CpG and UpA dinucleotides is restricted in the genomes of animal RNA viruses to avoid specific host defenses. We wondered whether a similar phenomenon exists in nonanimal RNA viruses. Here, we show that these two dinucleotides, especially UpA, are underrepresented in the family

Indexed as

Genome, ViralAntiviral AgentsCpG IslandsDinucleoside PhosphatesDNA VirusesGenomic InstabilityPlant DiseasesPlant VirusesPlum Pox VirusPotyviridaePotyvirusRNA InterferenceRNA, MessengerRNA Polymerase IIRNA, ViralVirus DiseasesAntiviral AgentsDinucleoside PhosphatesRNA, MessengerRNA Polymerase IIRNA, Viraluridylyl-(3'-5')-adenosineantiviralplant defenseplant-microbe interactionsPotyviridaepotyvirusRNA degradationRNA virusvirus

Identifiers

PMID32071264
PMCPMC7029135
OpenAlexW3007937996

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.