Evidence map›Paper›PMID 32071548›Full record

ArticleInternational journal of biological sciences2020

Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-like Cells by Inhibiting Autophagy in Vitro and in

Yuan Ke, Chaoyan Wu, Yifei Zeng, Mengge Chen, Yonghong Li, Conghua Xie, Yunfeng Zhou, Yahua Zhong, Haijun Yu

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yuan KeDepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Chaoyan WuDepartment of Integrated Traditional Chinese Medicine and Western medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yifei ZengDepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Mengge ChenDepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yonghong LiDepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Conghua XieDepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yunfeng ZhouDepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yahua ZhongDepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Haijun YuDepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wuhan University · CNZhongnan Hospital of Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loco-regional recurrence of nasopharyngeal carcinoma (NPC) after radiation therapy is one of the main types of treatment failure. This study is aimed to explore the possible causes of inside-field recurrence of NPC patients in order to develop effective treatment methods. Our study indicated that CD44 and autophagy proteins in tumor tissues of patients with recurrent NPC are higher than that of the relapse free patients. The

Indexed as

AnimalsApoptosisAutophagyBeclin-1Blotting, WesternCell Line, TumorCell ProliferationClioquinolFemaleFlow CytometryGene Expression Regulation, NeoplasticImmunohistochemistryMaleMice, Inbred BALB CMicrotubule-Associated ProteinsNasopharyngeal CarcinomaBeclin-1ClioquinolMAP1LC3A protein, humanMicrotubule-Associated ProteinsZinc

Identifiers

PMID32071548
PMCPMC7019136
OpenAlexW3003936523

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.