Evidence map›Paper›PMID 32071920›Full record

ArticleBioMed research international2020

Germacrone Inhibits Cell Proliferation and Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cells.

Ren Zhang, Ji Hao, Kaiwen Guo, Wanxin Liu, Fei Yao, Qingming Wu, Chang Liu, Qiang Wang, Xinzhou Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Chinese herbal medicines · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ren ZhangInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China.ORCID https://orcid.org/0000-0001-9039-5146
Ji HaoSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Kaiwen GuoInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China.
Wanxin LiuInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China.
Fei YaoInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China.
Qingming WuInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China.ORCID https://orcid.org/0000-0002-8009-1867
Chang LiuSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Qiang WangInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China.ORCID https://orcid.org/0000-0001-7420-8646
Xinzhou YangSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.ORCID https://orcid.org/0000-0003-1697-2923
Wuhan University of Science and Technology · CNSouth Central Minzu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Germacrone, a natural 10-membered monocyclic sesquiterpene with three double bonds and a ketone, was isolated from the roots of traditional Chinese medicine

Indexed as

Apoptosisbcl-2-Associated X ProteinCaspase 3Caspase 9Cell Line, TumorCell ProliferationCell SurvivalEndoplasmic Reticulum Chaperone BiPEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaHeat-Shock ProteinsHumansMedicine, Chinese TraditionalPhosphorylationPlant RootsProto-Oncogene Proteins c-bcl-2BAX protein, humanbcl-2-Associated X ProteinBCL2 protein, humanCaspase 3Caspase 9Endoplasmic Reticulum Chaperone BiPgermacroneHeat-Shock ProteinsHSPA5 protein, humanProto-Oncogene Proteins c-bcl-2Sesquiterpenes, GermacraneSTAT3 protein, humanSTAT3 Transcription Factor

Identifiers

PMID32071920
PMCPMC7011320
OpenAlexW3003394636

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.