Evidence map›Paper›PMID 32075045›Full record

ArticleMolecules (Basel, Switzerland)2020

Ginseng Extract Ameliorates the Negative Physiological Effects of Heat Stress by Supporting Heat Shock Response and Improving Intestinal Barrier Integrity: Evidence from Studies with Heat-Stressed Caco-2 Cells,

Georg Sandner, Andreas S Mueller, Xiaodan Zhou, Verena Stadlbauer, Bettina Schwarzinger, Clemens Schwarzinger, Uwe Wenzel, Klaus Maenner, Jan Dirk van der Klis, Stefan Hirtenlehner and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Article
  6. Antiaging Effect of 2-Foods (Basel, Switzerland) · 2025
    Article
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  19. Article
  20. Editorial: Relieving stress response in animals.Frontiers in veterinary science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Georg SandnerUniversity of Applied Sciences Upper Austria, School of Engineering and Environmental Sciences, Stelzhamerstraße 23, 4600 Wels, Austria.
Andreas S MuellerDelacon Biotechnik GmbH, Weissenwolffstraße 14, 4221 Steyregg, Austria.
Xiaodan ZhouDelacon Biotechnik GmbH, Weissenwolffstraße 14, 4221 Steyregg, Austria.
Verena StadlbauerUniversity of Applied Sciences Upper Austria, School of Engineering and Environmental Sciences, Stelzhamerstraße 23, 4600 Wels, Austria.
Bettina SchwarzingerUniversity of Applied Sciences Upper Austria, School of Engineering and Environmental Sciences, Stelzhamerstraße 23, 4600 Wels, Austria.
Clemens SchwarzingerJohannes Kepler University, Institute for Chemical Technology of Organic Materials, 4040 Linz, Austria.
Uwe WenzelMolecular Nutrition Research, Interdisciplinary Research Centre, Justus-Liebig-University of Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.
Klaus MaennerInstitute of Animal Nutrition of Free University Berlin, Königin-Luise-Str.49, 14195 Berlin, Germany.
Jan Dirk van der KlisDelacon Biotechnik GmbH, Weissenwolffstraße 14, 4221 Steyregg, Austria.
Stefan HirtenlehnerDelacon Biotechnik GmbH, Weissenwolffstraße 14, 4221 Steyregg, Austria.
Tobias AumillerDelacon Biotechnik GmbH, Weissenwolffstraße 14, 4221 Steyregg, Austria.
Julian WeghuberUniversity of Applied Sciences Upper Austria, School of Engineering and Environmental Sciences, Stelzhamerstraße 23, 4600 Wels, Austria.
University of Applied Sciences Upper Austria · ATJohannes Kepler University of Linz · ATFreie Universität Berlin · DEJustus-Liebig-Universität Gießen · DE

Funding

Christian Doppler Forschungsgesellschaft Josef Ressel Center for Phytogenic Drug ResearchÖsterreichische Forschungsförderungsgesellschaft 854182
6 · The paper itself

Abstract

Climatic changes and heat stress have become a great challenge in the livestock industry, negatively affecting, in particular, poultry feed intake and intestinal barrier malfunction. Recently, phytogenic feed additives were applied to reduce heat stress effects on animal farming. Here, we investigated the effects of ginseng extract using various in vitro and in vivo experiments. Quantitative real-time PCR, transepithelial electrical resistance measurements and survival assays under heat stress conditions were carried out in various model systems, including Caco-2 cells,

Indexed as

AnimalsCaco-2 CellsCaenorhabditis elegansCaenorhabditis elegans ProteinsChickensClaudin-1Claudin-3Gene Expression RegulationHeat-Shock ResponseHeat Stress DisordersHSP70 Heat-Shock ProteinsHumansJejunumPanaxPlant ExtractsCaenorhabditis elegans ProteinsClaudin-1Claudin-3CLDN1 protein, humanCLDN3 protein, humanHSP-1 protein, C elegansHSP70 Heat-Shock ProteinsHSPA1A protein, humanPlant ExtractsbroilerGinseng extractheat stressintestinal barrier

Identifiers

PMID32075045
PMCPMC7070719
OpenAlexW3006629840

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.