Evidence map›Paper›PMID 32076569›Full record

ArticleCanadian journal of kidney health and disease2020

Major Outcomes With Personalized Dialysate TEMPerature (MyTEMP): Rationale and Design of a Pragmatic, Registry-Based, Cluster Randomized Controlled Trial.

Ahmed A Al-Jaishi, Christopher W McIntyre, Jessica M Sontrop, Stephanie N Dixon, Sierra Anderson, Amit Bagga, Derek Benjamin, David Berry, Peter G Blake, Laura Chambers and 34 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of kidney health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02628366 (Major Outcomes With Personalized Dialysate TEMPerature), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02628366 nacompletednot on this map

Major Outcomes With Personalized Dialysate TEMPerature: Pragmatic, Registry-Based, Cluster Randomized Controlled Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2017 to 2021Enrolled84ConditionsKidney Diseases, End-Stage Kidney Disease, HemodialysisArmsPersonalized Dialysate Temperature
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
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  6. Dialysis and cognitive impairment.Nature reviews. Nephrology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 20 institutions in 2 countries.

Ahmed A Al-JaishiLondon Health Sciences Centre, ON, Canada.ORCID https://orcid.org/0000-0003-0376-2214
Christopher W McIntyreLondon Health Sciences Centre, ON, Canada.
Jessica M SontropLondon Health Sciences Centre, ON, Canada.
Stephanie N DixonLondon Health Sciences Centre, ON, Canada.
Sierra AndersonLondon Health Sciences Centre, ON, Canada.
Amit BaggaWindsor Regional Hospital, ON, Canada.
Derek BenjaminRoyal Victoria Hospital, Barrie, ON, Canada.
David BerrySault Area Hospital, Sault Ste. Marie, ON, Canada.
Peter G BlakeLondon Health Sciences Centre, ON, Canada.
Laura ChambersLondon Health Sciences Centre, ON, Canada.
Patricia C K ChanMichael Garron Hospital, Toronto, ON, Canada.
Nicole DelbrouckRenfrew Victoria Hospital, ON, Canada.
P J DevereauxMcMaster University, Hamilton, ON, Canada.
Luis F Ferreira-DivinoLondon Health Sciences Centre, ON, Canada.
Richard GoluchHealth Sciences North, Sudbury, ON, Canada.
Laura GregorGrand River Hospital, Kitchener, ON, Canada.
Jeremy M GrimshawOttawa Hospital Research Institute, ON, Canada.
Garth HansonPeterborough Regional Health Centre, ON, Canada.
Eduard IliescuKingston Health Sciences Centre, ON, Canada.
Arsh K JainLondon Health Sciences Centre, ON, Canada.
Charmaine E LokUniversity Health Network, Toronto, ON, Canada.
Reem A MustafaMcMaster University, Hamilton, ON, Canada.
Bharat NathooMackenzie Health, Richmond Hill, ON, Canada.
Gihad E NesrallahHumber River Regional Hospital, Toronto, ON, Canada.
Matthew J OliverSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Sanjay PandeyaHalton Healthcare, Oakville, ON, Canada.
Malvinder S ParmarTimmins and District Hospital, ON, Canada.
David PerkinsTrillium Health Partners, Mississauga, ON, Canada.
Justin PresseauOttawa Hospital Research Institute, ON, Canada.
Eli RabinNiagara Health System, St. Catharines, ON, Canada.
Joanna SasalSt. Joseph's Health Centre, Toronto, ON, Canada.
Tanya ShulmanNorth Bay Regional Health Centre, ON, Canada.
Manish M SoodICES, ON, Canada.ORCID https://orcid.org/0000-0002-9146-2344
Andrew SteeleLakeridge Health Corporation, Oshawa, ON, Canada.
Paul TamScarborough Health Network, ON, Canada.
Daniel TasconaOrillia Soldiers' Memorial Hospital, ON, Canada.
Davinder WadehraWilliam Osler Health Centre, Brampton, ON, Canada.
Ron WaldICES, ON, Canada.ORCID https://orcid.org/0000-0003-4411-8169
Michael WalshMcMaster University, Hamilton, ON, Canada.
Paul WatsonThunder Bay Regional Health Sciences Centre, ON, Canada.
Walter WodchisICES, ON, Canada.
Phillip ZagerDialysis Clinic Inc, Nashville, TN, USA.
Merrick ZwarensteinICES, ON, Canada.
Amit X GargLondon Health Sciences Centre, ON, Canada.ORCID https://orcid.org/0000-0003-3398-3114
Western University · CALondon Health Sciences Centre · CAUniversity of Ottawa · CAThunder Bay Regional Health Sciences Centre · CAGrand River Hospital · CAHalTech · CAHealth Sciences North · CAHumber River Regional Hospital · CAKingston Health Sciences Centre · CALakeridge Health · CAMcMaster University · CANiagara Health System · CARoyal Victoria Regional Health Centre · CASault Area Hospital · CASt. Joseph’s Healthcare Hamilton · CASt Joseph's Health Centre · CASt. Michael's Hospital · CASunnybrook Health Science Centre · CAThe Scarborough Hospital · CAToronto East General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmall randomized trials demonstrated that a lower compared with higher dialysate temperature reduced the average drop in intradialytic blood pressure. Some observational studies demonstrated that a lower compared with higher dialysate temperature was associated with a lower risk of all-cause mortality and cardiovascular mortality. There is now the need for a large randomized trial that compares the effect of a low vs high dialysate temperature on major cardiovascular outcomes.

objectiveThe purpose of this study is to test the effect of outpatient hemodialysis centers randomized to (1) a personalized temperature-reduced dialysate protocol or (2) a standard-temperature dialysate protocol for 4 years on cardiovascular-related death and hospitalizations.

designThe design of the study is a pragmatic, registry-based, open-label, cluster randomized controlled trial.

settingHemodialysis centers in Ontario, Canada, were randomized on February 1, 2017, for a trial start date of April 3, 2017, and end date of March 31, 2021.

participantsIn total, 84 hemodialysis centers will care for approximately 15 500 patients and provide over 4 million dialysis sessions over a 4-year follow-up.

interventionHemodialysis centers were randomized (1:1) to provide (1) a personalized temperature-reduced dialysate protocol or (2) a standard-temperature dialysate protocol of 36.5°C. For the personalized protocol, nurses set the dialysate temperature between 0.5°C and 0.9°C below the patient's predialysis body temperature for each dialysis session, to a minimum dialysate temperature of 35.5°C. PRIMARY OUTCOME: A composite of cardiovascular-related death or major cardiovascular-related hospitalization (a hospital admission with myocardial infarction, congestive heart failure, or ischemic stroke) captured in Ontario health care administrative databases. PLANNED PRIMARY ANALYSIS: The primary analysis will follow an intent-to-treat approach. The hazard ratio of time-to-first event will be estimated from a Cox model. Within-center correlation will be considered using a robust sandwich estimator. Observation time will be censored on the trial end date or when patients die from a noncardiovascular event.

trial registrationwww.clinicaltrials.gov; identifier: NCT02628366.

Indexed as

cardiovascular eventscluster randomized controlled trialdialysisdialysis solutionsmortalitypersonalized dialysate temperaturepragmatic trial

Identifiers

PMID32076569
PMCPMC7003172
OpenAlexW3005523777

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.