Evidence map›Paper›PMID 32078009›Full record

ArticleAnnals of hematology2020

Implementation of RNA sequencing and array CGH in the diagnostic workflow of the AIEOP-BFM ALL 2017 trial on acute lymphoblastic leukemia.

Maximilian Schieck, Jana Lentes, Kathrin Thomay, Winfried Hofmann, Yvonne Lisa Behrens, Maike Hagedorn, Juliane Ebersold, Colin F Davenport, Grazia Fazio, Anja Möricke and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Annals of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
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  7. Challenging the prognostic expectations: a rare case ofBlood science (Baltimore, Md.) · 2025
    Article
  8. Review
  9. Article
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  12. Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Article
  13. Article
  14. Resistance Mechanisms in Pediatric B-Cell Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Maximilian SchieckDepartment of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. schieck.maximilian@mh-hannover.de.ORCID http://orcid.org/0000-0001-5878-0546
Jana LentesDepartment of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Kathrin ThomayDepartment of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Winfried HofmannDepartment of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Yvonne Lisa BehrensDepartment of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Maike HagedornDepartment of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Juliane EbersoldDepartment of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Colin F DavenportResearch Core Unit Genomics, Hannover Medical School, Hannover, Germany.
Grazia FazioCentro Ricerca Tettamanti, Pediatric Clinic, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy.
Anja MörickeDepartment of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Swantje BuchmannDepartment of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Julia AltenDepartment of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Gunnar CarioDepartment of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Martin SchrappeDepartment of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Anke Katharina BergmannDepartment of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Martin StanullaPediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
Doris SteinemannDepartment of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Brigitte SchlegelbergerDepartment of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Giovanni CazzanigaCentro Ricerca Tettamanti, Pediatric Clinic, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy.
Gudrun GöhringDepartment of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Medizinische Hochschule Hannover · DEUniversity Hospital Schleswig-Holstein · DEUniversity of Milano-Bicocca · IT

Funding

Deutsche Forschungsgemeinschaft BE 6555/1-1Deutsche Forschungsgemeinschaft BE 6555/2-1Deutsche Forschungsgemeinschaft Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy)Medizinischen Hochschule Hannover HochschulinterneLeistungsförderung (HiLF)
6 · The paper itself

Abstract

Risk-adapted therapy has significantly contributed to improved survival rates in pediatric acute lymphoblastic leukemia (ALL) and reliable detection of chromosomal aberrations is mandatory for risk group stratification. This study evaluated the applicability of panel-based RNA sequencing and array CGH within the diagnostic workflow of the German study group of the international AIEOP-BFM ALL 2017 trial. In a consecutive cohort of 117 children with B cell precursor (BCP) ALL, array analysis identified twelve cases with an IKZF1

Indexed as

Comparative Genomic HybridizationSequence Analysis, RNAAbnormal KaryotypeAntineoplastic Combined Chemotherapy ProtocolsAsparaginaseCyclophosphamideCytarabineDaunorubicinGenes, NeoplasmHumansIkaros Transcription FactorIn Situ Hybridization, FluorescenceMercaptopurineMethotrexateNeoplasm ProteinsPrecursor Cell Lymphoblastic Leukemia-LymphomaAsparaginaseCyclophosphamideCytarabineDaunorubicinIkaros Transcription FactorIKZF1 protein, humanMercaptopurineMethotrexateNeoplasm ProteinsPrednisoneRNA, MessengerRNA, NeoplasmVincristineAcute lymphoblastic leukemiaDiagnosticsFusion transcriptIKZF1plusRisk stratificationRNA sequencing

Identifiers

PMID32078009
PMCPMC7069912
OpenAlexW3007939309

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.