Evidence map›Paper›PMID 32083995›Full record

ReviewJournal of clinical oncology : official journal of the American Society of Clinical Oncology2020

Genomic Landscape of Waldenström Macroglobulinemia and Its Impact on Treatment Strategies.

Steven P Treon, Lian Xu, Maria Luisa Guerrera, Cristina Jimenez, Zachary R Hunter, Xia Liu, Maria Demos, Joshua Gustine, Gloria Chan, Manit Munshi and 14 more

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04463953 (A Phase 2 Clinical Trial to Evaluate the Efficacy of Zanubrutinib Plus Ixazomib and Dexamethasone in Newly Diagnosed Symptomatic Waldenström Macroglobulinemia), which is not on this map. Cited by 92 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 2 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04463953 phase2completednot on this map

A Phase 2 Clinical Trial to Evaluate the Efficacy of Zanubrutinib Plus Ixazomib and Dexamethasone in Newly Diagnosed Symptomatic Waldenström Macroglobulinemia

TypeinterventionalSponsorInstitute of Hematology & Blood Diseases Hospital, ChinaRan2020 to 2022Enrolled25ConditionsWaldenström MacroglobulinemiaArmsZanubrutinib,Ixazomib and Dexamethasone
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Venetoclax in Previously Treated Waldenström Macroglobulinemia.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Trial
  6. Trial
  7. A Phase II Trial of the Bruton Tyrosine-Kinase Inhibitor Zanubrutinib (BGB-3111) in Patients with Relapsed/Refractory Waldenström Macroglobulinemia.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Trial
  8. Trial
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 2 countries.

Steven P TreonBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Lian XuBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Maria Luisa GuerreraBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Cristina JimenezBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Zachary R HunterBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Xia LiuBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Maria DemosBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Joshua GustineBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Gloria ChanBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Manit MunshiBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Nicholas TsakmaklisBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Jiaji G ChenBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Amanda KofidesBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Romanos Sklavenitis-PistofidisDepartment of Medicine, Harvard Medical School, Boston, MA.
Mark BustorosDepartment of Medicine, Harvard Medical School, Boston, MA.
Andrew KeezerBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Kirsten MeidBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Christopher J PattersonBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Antonio SaccoCenter for Prevention of Progression of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA.
Aldo RoccaroClinical Research Development and Phase I Unit, CREA Laboratory, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Italy.
Andrew R BranaganDivision of Hematology and Oncology, Massachusetts General Hospital, Boston, MA.
Guang YangBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Irene M GhobrialDepartment of Medicine, Harvard Medical School, Boston, MA.
Jorge J CastilloBing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA.
Dana-Farber Cancer Institute · USHarvard University · USAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITMassachusetts General Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Trageting the Multiple Myeloma EpigenomeP50CA100707 · NCI · DANA-FARBER CANCER INSTITUTE · PI ANDERSON, KENNETH C., MUNSHI, NIKHIL C. · 2003 to 2023
$45.0M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P50 CA100707
6 · The paper itself

Abstract

Next-generation sequencing has revealed recurring somatic mutations in Waldenström macroglobulinemia (WM), including

Indexed as

MutationDNA Copy Number VariationsGenomicsHumansMyeloid Differentiation Factor 88Pathology, MolecularReceptors, CXCR4Waldenstrom MacroglobulinemiaCXCR4 protein, humanMYD88 protein, humanMyeloid Differentiation Factor 88Receptors, CXCR4

Identifiers

PMID32083995
PMCPMC7351339
OpenAlexW3008151606

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.