Evidence map›Paper›PMID 32085381›Full record

ReviewMolecules (Basel, Switzerland)2020

Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues.

Danielly C Ferraz da Costa, Luciana Pereira Rangel, Mafalda Maria Duarte da Cunha Martins-Dinis, Giulia Diniz da Silva Ferretti, Vitor F Ferreira, Jerson L Silva

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Controlled Self-Immolative Release of β-Lapachone via an OptimizedJournal of the American Chemical Society · 2025
    Article
  6. Review
  7. Article
  8. Antifungal activity of β-lapachone against a fluconazole-resistant Candida auris strain.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  9. Review
  10. Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Naphth[1,2-Molecules (Basel, Switzerland) · 2023
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Danielly C Ferraz da CostaDepartamento de Nutrição Básica e Experimental, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20550-013, Brazil.
Luciana Pereira RangelFaculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0002-6154-0815
Mafalda Maria Duarte da Cunha Martins-DinisPrograma de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Giulia Diniz da Silva FerrettiPrograma de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Vitor F FerreiraDepartamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Rio de Janeiro 24241-000, Brazil.
Jerson L SilvaPrograma de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0001-9523-9441

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 465395/2014-7Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 210008/2018
6 · The paper itself

Abstract

This review aims to explore the potential of resveratrol, a polyphenol stilbene, and beta-lapachone, a naphthoquinone, as well as their derivatives, in the development of new drug candidates for cancer. A brief history of these compounds is reviewed along with their potential effects and mechanisms of action and the most recent attempts to improve their bioavailability and potency against different types of cancer.

Indexed as

Antineoplastic AgentsHumansInhibitory Concentration 50NaphthoquinonesNeoplasmsResveratrolTumor Suppressor Protein p53Antineoplastic Agentsbeta-lapachoneNaphthoquinonesResveratrolTumor Suppressor Protein p53cancerresveratrolβ-lapachone

Identifiers

PMID32085381
PMCPMC7070981

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.