ArticleEuropean radiology2020
Bone marrow fat fraction assessment in regard to physical activity: KORA FF4-3-T MR imaging in a population-based cohort.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 d of bed rest.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Trial
- Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss.Nutrients · 2020Trial
- Association of habitual diet and bone marrow adipose tissue - magnetic resonance imaging in a population-based sample.Nutrition journal · 2026Article
- Obesity surgery improves metabolic dysfunction-associated steatotic liver disease and type 2 diabetes - MRI and biochemical analysis of liver and pancreas.Surgery open science · 2026Article
- Long-term effect of physical inactivity on osteosarcopenic obesity - a MRI-based investigation from a population-based cohort.BMC musculoskeletal disorders · 2025Observational
- Bone loss and increased bone marrow adiposity in ovary-intact and ovariectomized rats with chronic obstructive pulmonary disease.Journal of endocrinological investigation · 2025Article
- Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk.Nature communications · 2025Article
- Fat Fraction and Iron Concentration in Lumbar Vertebral Bone Marrow in the UK Biobank.Obesity science & practice · 2025Article
- Preliminary study of proton magnetic resonance spectroscopy to assess bone marrow adiposity in the third metacarpus or metatarsus in Thoroughbred racehorses.Equine veterinary journal · 2025Article
- MRI-Based Phenotyping for Osteosarcopenic Adiposity in Subjects from a Population-Based Cohort.Geriatrics (Basel, Switzerland) · 2024Article
- Association between myosteatosis and impaired glucose metabolism: A deep learning whole-body magnetic resonance imaging population phenotyping approach.Journal of cachexia, sarcopenia and muscle · 2024Article
- Function and Regulation of Bone Marrow Adipose Tissue in Health and Disease: State of the Field and Clinical Considerations.Comprehensive Physiology · 2024Review
- Obesity, diabetes and risk of bone fragility: How BMAT behavior is affected by metabolic disturbances and its influence on bone health.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Review
- Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging.International journal of molecular sciences · 2023Review
- Association of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study.European radiology · 2023Article
- Bone marrow adiposity in diabetes and clinical interventions.Current opinion in endocrinology, diabetes, and obesity · 2022Review
- Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis.Seminars in cell & developmental biology · 2022Review
- Effects of Total Flavonoids of Epimedium on Bone Marrow Adipose Tissue in Ovariectomized Rats.Frontiers in endocrinology · 2022Article
- Quantitative evaluation of bone marrow fat content and unsaturated fatty index in young male soccer players using proton magnetic resonance spectroscopy (Quantitative imaging in medicine and surgery · 2021Article
- The Impact of Sedentary Lifestyle, High-fat Diet, Tobacco Smoke, and Alcohol Intake on the Hematopoietic Stem Cell Niches.HemaSphere · 2021Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectivesTo establish the effect of different degrees and kinds of physical activity on bone marrow fat (BMAT) content at different anatomical locations in a population-based cohort study undergoing whole-body MR imaging.
methodsSubjects of the KORA FF4 study without known cardiovascular disease underwent BMAT fat fraction (FF) quantification in L1 and L2 vertebrae and femoral heads/necks (hip) via a 2-point T1-weighted VIBE Dixon sequence. BMAT-FF was calculated as mean value (fat image) divided by mean value (fat + water image). Physical activity was determined by self-assessment questionnaire regarding time spent exercising, non-exercise walking, non-exercise cycling, and job-related physical activity.
resultsA total of 385 subjects (96% of 400 available; 56 ± 9.1 years; 58% male) were included in the analysis. Exercise was distributed quite evenly (29% > 2 h/week; 31% ~ 1 h/week (regularly); 15% ~ 1 h/week (irregularly); 26% no physical activity). BMAT-FF was 52.6 ± 10.2% in L1, 56.2 ± 10.3% in L2, 87.4 ± 5.9% in the right hip, and 87.2 ± 5.9% in the left hip (all p < 0.001). Correlation of BMAT-FF between spine and hip was only moderate (r 0.42 to 0.46). Spinal BMAT-FF, but not hip BMAT-FF, was inversely associated with exercise > 2 h/week (p ≤ 0.02 vs. p ≥ 0.35, respectively). These associations remained significant after adjusting for age, gender, waist circumference, and glucose tolerance. No coherent association was found between BMAT-FF and physical activity in the less active groups.
conclusionsIn our study, exercise was inversely correlated with vertebral BMAT-FF, but not hip BMAT-FF, when exercising for more than 2 h per week. Physical activity seems to affect the spine at least preferentially compared to the hip. KEY POINTS: • In our population-based cohort, at least 2 h of physical activity per week were required to show lower levels of bone marrow adipose tissue fat fraction in MRI. • Physical activity seems to affect bone marrow adipose tissue at least preferentially at the spine in contrast to the proximal femur.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.