Evidence map›Paper›PMID 32089885›Full record

ArticleInternational journal of vascular medicine2019

Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats.

Kelston Paulo Felice de Sales, Bruno Araújo Serra Pinto, Nathalee Liberal Xavier Ribeiro, Thamys Marinho Melo, Leonardo Victor Galvão-Moreira, Sebastião Barreto de Brito Filho, Flávio Nigri

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In one paragraph

Article in International journal of vascular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kelston Paulo Felice de SalesDepartment of Vascular and Endovascular Surgery, University Hospital, Federal University of Maranhão, São Luís, Brazil.ORCID https://orcid.org/0000-0002-0162-8049
Bruno Araújo Serra PintoLaboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, São Luís, Brazil.
Nathalee Liberal Xavier RibeiroLaboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, São Luís, Brazil.
Thamys Marinho MeloLaboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, São Luís, Brazil.
Leonardo Victor Galvão-MoreiraSchool of Medicine, Federal University of Maranhão, São Luís, Brazil.ORCID https://orcid.org/0000-0003-4913-8783
Sebastião Barreto de Brito FilhoDepartment of Vascular and Endovascular Surgery, University Hospital, Federal University of Maranhão, São Luís, Brazil.
Flávio NigriHead of Neurosurgery Teaching and Assistance Unit, Department of Surgical Specialties, Pedro Ernesto University Hospital, Nervous System Electric Stimulation Laboratory (LabEEL) - Neurosurgery Teaching and Assistance Unit, Pedro Ernesto University Hospital, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Universidade Federal do Maranhão · BRUniversidade do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReperfusion syndrome after carotid endarterectomy is a complication associated with cerebrovascular self-regulation in a chronically hypoperfused cerebral hemisphere, leading to severe neurological damage. Vitamin C is an important antioxidant in brain metabolism that has shown some neuroprotective actions.

objectiveTo investigate the potential effects of vitamin C on cerebral reperfusion in comparison with placebo (saline) in rats.

methodsMale Wistar rats were divided into 3 groups: (i) Sham (

resultsRats treated with vitamin C presented with a similar behavior as compared to the Sham group in all the three tests (

conclusionIn the present study, vitamin C was associated with behavioral and motor preservation as well as decreased cerebral MDA levels after induced cerebral ischemia in rats.

Identifiers

PMID32089885
PMCPMC7012208
OpenAlexW2996250790

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.