Evidence map›Paper›PMID 32093165›Full record

ReviewInternational journal of molecular sciences2020

Homocysteine: Its Possible Emerging Role in At-Risk Population Groups.

Elena Azzini, Stefania Ruggeri, Angela Polito

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 5 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. Pooled it
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  6. Trial
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  9. Review
  10. Hypertension in middle childhood.BMC pediatrics · 2026
    Article
  11. Comparative urinary metabolomics reveals unique and shared pathways in COVID-19 and liver diseases.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  12. BlackOpen veterinary journal · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. PMEnvironmental health : a global access science source · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Homocysteine and thyroid diseases.Frontiers in endocrinology · 2025
    Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Elena AzziniCREA-Research Centre for Food and Nutrition Via Ardeatina, 546 Rome, Italy.ORCID 0000-0002-1971-1668
Stefania RuggeriCREA-Research Centre for Food and Nutrition Via Ardeatina, 546 Rome, Italy.
Angela PolitoCREA-Research Centre for Food and Nutrition Via Ardeatina, 546 Rome, Italy.
Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased plasma homocysteine is a risk factor for several pathological disorders. The present review focused on the role of homocysteine (Hcy) in different population groups, especially in risk conditions (pregnancy, infancy, old age), and on its relevance as a marker or etiological factor of the diseases in these age groups, focusing on the nutritional treatment of elevated Hcy levels. In pregnancy, Hcy levels were investigated in relation to the increased risk of adverse pregnancy outcomes such as small size for gestational age at birth, preeclampsia, recurrent abortions, low birth weight, or intrauterine growth restriction. In pediatric populations, Hcy levels are important not only for cardiovascular disease, obesity, and renal disease, but the most interesting evidence concerns study of elevated levels of Hcy in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Finally, a focus on the principal pathologies of the elderly (cardiovascular and neurodegenerative disease, osteoporosis and physical function) is presented. The metabolism of Hcy is influenced by B vitamins, and Hcy-lowering vitamin treatments have been proposed. However, clinical trials have not reached a consensus about the effectiveness of vitamin supplementation on the reduction of Hcy levels and improvement of pathological condition, especially in elderly patients with overt pathologies, suggesting that other dietary and non-dietary factors are involved in high Hcy levels. The importance of novel experimental designs focusing on intra-individual variability as a complement to the typical case-control experimental designs and the study of interactions between different factors it should be emphasized.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderCardiovascular DiseasesNeurodegenerative DiseasesOsteoporosisPre-EclampsiaAgingFemaleHomocysteineHumansInfant, NewbornInfant, Small for Gestational AgeMalePregnancyRisk FactorsHomocysteineadolescentschildrenelderlyhomocysteinepregnancy

Identifiers

PMID32093165
PMCPMC7073042
OpenAlexW3009019194

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.