Evidence map›Paper›PMID 32096122›Full record

ArticleJournal of autism and developmental disorders2020

Brief Report: Genetic Links Between Autism and Suicidal Behavior-A Preliminary Investigation.

Emily DiBlasi, Anne V Kirby, Eoin Gaj, Anna R Docherty, Brooks R Keeshin, Amanda V Bakian, Hilary Coon

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emily DiBlasiDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Anne V KirbyDepartment of Occupational and Recreational Therapies, University of Utah, 520 Wakara Way, Salt Lake City, UT, USA. avkirby@gmail.com.ORCID http://orcid.org/0000-0003-0395-6684
Eoin GajDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Anna R DochertyDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Brooks R KeeshinDepartment of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
Amanda V BakianDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Hilary CoonDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Genetic analysis of high-risk Utah suicide pedigreesR01MH099134 · NIMH · UNIVERSITY OF UTAH · PI COON, HILARY · 2013 to 2017
$3.9M
Genome-Wide Association Analysis of Suicide DeathR01MH123619 · NIMH · UNIVERSITY OF UTAH · PI DOCHERTY, ANNA R. · 2020 to 2024
$3.2M
Genetic risk discovery using WGS from a population-based resource of 10,000 suicide deaths with DNAR01MH122412 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Hilary Coon · 2020 to 2026
$2.7M
University of Utah Center for clinical and Translational ScienceKL2TR001065 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$1.1M
Modeling Dimensionality and Genetic Heterogeneity in SchizophreniaK01MH109765 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI DOCHERTY, ANNA R. · 2016 to 2019
$675k
Integrating Genomic and Environmental Perspectives on Internalizing DisordersK01MH093731 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI ADKINS, DANIEL E · 2011 to 2015
$649k
NCATS NIH HHS KL2 TR001065NCATS NIH HHS KL2TR001065NCATS NIH HHS UL1 TR002538NIMH NIH HHS K01 MH093731NIMH NIH HHS K01MH093731NIMH NIH HHS K01 MH109765NIMH NIH HHS R01 MH099134NIMH NIH HHS R01MH099134NIMH NIH HHS R01 MH122412NIMH NIH HHS R01 MH123619
6 · The paper itself

Abstract

Evidence suggests there may be increased risk for suicidal behavior among individuals with autism spectrum disorder (ASD). An emerging body of research explores social factors that may contribute to increased risk, however little is known about the potential role of biological factors. The current project addresses this knowledge gap through a preliminary study of genes associated with both ASD and suicidal behavior. Gene set enrichment tests of eight genes strongly associated with both ASD and suicidal behavior revealed overrepresentation of nine biological processes, including cognition and synapse function, and 14 cellular components, including the neuron, the synapse, and the synaptic and postsynaptic membrane. These results can be used to inform future investigations of the biological underpinnings of suicidal behavior and ASD.

Indexed as

Suicidal IdeationAdultAutism Spectrum DisorderFemaleGenetic LinkageHumansMaleAutismGene set enrichmentGeneticSuicide

Identifiers

PMID32096122
PMCPMC7483143

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.