ArticlePLoS biology2020
The unidentified hormonal defense against weight gain.
Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- LEAP2 as a therapeutic target in obesity and cardiometabolic disorders.Reviews in endocrine & metabolic disorders · 2026Review
- A nutrient-hormone axis pivots an energy trade-off between resting thermogenesis and movement expenditure.Journal of sport and health science · 2026Article
- Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.Cell reports · 2025Article
- Article
- Overfeeding induces adipose tissue release of distinct mitochondria.Cell reports · 2025Article
- Obesity as a disease: a pressing need for alignment.International journal of obesity (2005) · 2024Article
- Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R.Nature communications · 2024Article
- Protein appetite as an integrator in the obesity system: the protein leverage hypothesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Models of body weight and fatness regulation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- The dual hypothesis of homeostatic body weight regulation, including gravity-dependent and leptin-dependent actions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Physiological protection against weight gain: evidence from overfeeding studies and future directions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- The physiology of experimental overfeeding in animals.Molecular metabolism · 2022Review
- Obesity: an evolutionary context.Life metabolism · 2022Review
- Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse.Communications biology · 2022Article
- Management of Obesity in Adults with CKD.Journal of the American Society of Nephrology : JASN · 2021Review
- Challenging the dogma.International journal of obesity (2005) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human biology has evolved to keep body fat within a range that supports survival. During the last 25 years, obesity biologists have uncovered key aspects of physiology that prevent fat mass from becoming too low. In contrast, the mechanisms that counteract excessive adipose expansion are largely unknown. Evidence dating back to the 1950s suggests the existence of a blood-borne molecule that defends against weight gain. In this article, we discuss the research supporting an "unidentified factor of overfeeding" and models that explain its role in body weight control. If it exists, revealing the identity of this factor could end a long-lasting enigma of energy balance regulation and facilitate a much-needed breakthrough in the pharmacological treatment of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.