Evidence map›Paper›PMID 32098170›Full record

ArticlePlants (Basel, Switzerland)2020

The Analysis of the Editing Defects in the

Bastien Malbert, Matthias Burger, Mauricio Lopez-Obando, Kevin Baudry, Alexandra Launay-Avon, Barbara Härtel, Daniil Verbitskiy, Anja Jörg, Richard Berthomé, Claire Lurin and 2 more

Open access · goldAbstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Plant organellar RNA maturation.The Plant cell · 2023
    Review
  3. GRP23 plays a core role in E-type editosomes via interacting with MORFs and atypical PPR-DYWs inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  4. International journal of molecular sciences · 2022
    Article
  5. Article
  6. Article
  7. Functions of PPR Proteins in Plant Growth and Development.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Bastien MalbertUniversité Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2), 91405 Orsay, France.
Matthias BurgerMolekulare Botanik, Universität Ulm, 89069 Ulm, Germany.
Mauricio Lopez-ObandoUniversité Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2), 91405 Orsay, France.ORCID 0000-0002-1380-0643
Kevin BaudryUniversité Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2), 91405 Orsay, France.
Alexandra Launay-AvonUniversité Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2), 91405 Orsay, France.ORCID 0000-0002-1993-313X
Barbara HärtelMolekulare Botanik, Universität Ulm, 89069 Ulm, Germany.
Daniil VerbitskiyMolekulare Botanik, Universität Ulm, 89069 Ulm, Germany.
Anja JörgMolekulare Botanik, Universität Ulm, 89069 Ulm, Germany.
Richard BerthoméUniversité Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2), 91405 Orsay, France.
Claire LurinUniversité Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2), 91405 Orsay, France.
Mizuki TakenakaMolekulare Botanik, Universität Ulm, 89069 Ulm, Germany.
Etienne DelannoyUniversité Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2), 91405 Orsay, France.
Centre National de la Recherche Scientifique · FRUniversität Ulm · DE

Funding

Agence Nationale de la Recherche ANR-10-LABX-0040-SPS
6 · The paper itself

Abstract

C to U editing is one of the post-transcriptional steps which are required for the proper expression of chloroplast and mitochondrial genes in plants. It depends on several proteins acting together which include the PLS-class pentatricopeptide repeat proteins (PPR). DYW2 was recently shown to be required for the editing of many sites in both organelles. In particular almost all the sites associated with the E+ subfamily of PPR proteins are depending on DYW2, suggesting that DYW2 is required for the function of E+-type PPR proteins. Here we strengthened this link by identifying 16 major editing sites controlled by 3 PPR proteins: OTP90, a DYW-type PPR and PGN and MEF37, 2 E+-type PPR proteins. A re-analysis of the DYW2 editotype showed that the 49 sites known to be associated with the 18 characterized E+-type PPR proteins all depend on DYW2. Considering only the 288 DYW2-dependent editing sites as potential E+-type PPR sites, instead of the 795 known editing sites, improves the performances of binding predictions systems based on the PPR code for E+-type PPR proteins. However, it does not compensate for poor binding predictions.

Indexed as

Arabidopsisgenome containing organellesmutantspentatricopeptide repeat (PPR) proteinsRNA editing

Identifiers

PMID32098170
PMCPMC7076377
OpenAlexW3007679617

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.