ReviewInternational journal of molecular sciences2020
Sex/Gender-Specific Imbalance in CVD: Could Physical Activity Help to Improve Clinical Outcome Targeting CVD Molecular Mechanisms in Women?
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Association Between Patient Factors and the Effectiveness of Wearable Trackers at Increasing the Number of Steps per Day Among Adults With Cardiometabolic Conditions: Meta-analysis of Individual Patient Data From Randomized Controlled Trials.Journal of medical Internet research · 2022Pooled it
- Could Physical Activity Have any Role in Cardiovascular Disease Prevention in Prisoners? A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Unveiling sex dimorphism in the healthy cardiac anatomy: Fundamental differences between male and female heart shapes.The Journal of physiology · 2026Article
- Global and regional burden of cardiovascular diseases due to low physical activity from 1990 to 2021 and projections to 2045: a joinpoint regression and age-period-cohort analysis based on GBD 2021.Internal and emergency medicine · 2026Article
- Physical activity partners for women with cardiovascular disease risk: Proof-of-concept trial with daily assessment.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Sex Differences in the Impact of Physical Activity Across the Spectrum of Cardiovascular Disease.Current cardiology reports · 2026Review
- Article
- Huangqi Guizhi Wuwu decoction ameliorates myocardial damage in ovariectomized rats by regulating the structure and function of myocardial microvessels and intestinal flora.Microbiology spectrum · 2025Article
- Sex differences in cardiac remodeling after kidney transplantation.BMC nephrology · 2025Article
- Physical Activity Measurement Reactivity Among Midlife Adults With Elevated Risk for Cardiovascular Disease: Protocol for Coordinated Analyses Across Six Studies.JMIR research protocols · 2025Article
- Gender-specific dual effects of physical activity on depression and mortality: a nine-year cohort study in Chinese adults aged 45 and above.Frontiers in public health · 2025Article
- Educational intervention based on the Extended Parallel Process Model in promoting preventive behaviors of arteriosclerosis in female high-school students.Journal of education and health promotion · 2025Article
- Epigenetic modifications and transgenerational inheritance in women victims of violence (EWVV).Environmental epigenetics · 2025Review
- Erxian decoction ameliorates myocardial tissue damage through activating PI3K/AKT signaling pathway in ovariectomized rats.Annals of medicine · 2024Article
- Bayesian spatial-temporal analysis and determinants of cardiovascular diseases in Tanzania mainland.BMC medical research methodology · 2024Article
- Role of sex and training characteristics on exercise effects on cardiovascular aging: protocol for a systematic review with meta-analysis of randomized trials.Systematic reviews · 2024Article
- Review
- Machine-learning-based models to predict cardiovascular risk using oculomics and clinic variables in KNHANES.BioData mining · 2024Article
- Age-period-cohort analysis of ischemic stroke deaths attributable to physical inactivity in different income regions.Scientific reports · 2024Article
- Association Between Female Androgen Levels, Metabolic Syndrome, and Cardiovascular Disease: An NHANES Analysis (2013-2016).International journal of women's health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
In the last two decades, new insights have been gained regarding sex/gender-related differences in cardiovascular disease (CVD). CVD represents the leading cause of death worldwide in both men and women, accounting for at least one-third of all deaths in women and half of deaths in women over 50 years in developing countries. Important sex-related differences in prevalence, presentation, management, and outcomes of different CVDs have been recently discovered, demonstrating sex/gender-specific pathophysiologic features in the presentation and prognosis of CVD in men and women. A large amount of evidence has highlighted the role of sex hormones in protecting women from CVDs, providing an advantage over men that is lost when women reach the menopause stage. This hormonal-dependent shift of sex-related CVD risk consequently affects the overall CVD epidemiology, particularly in light of the increasing trend of population aging. The benefits of physical activity have been recognized for a long time as a powerful preventive approach for both CVD prevention and aging-related morbidity control. Exercise training is indeed a potent physiological stimulus, which reduces primary and secondary cardiovascular events. However, the underlying mechanisms of these positive effects, including from a sex/gender perspective, still need to be fully elucidated. The aim of this work is to provide a review of the evidence linking sex/gender-related differences in CVD, including sex/gender-specific molecular mediators, to explore whether sex- and gender-tailored physical activity may be used as an effective tool to prevent CVD and improve clinical outcomes in women.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.