Evidence map›Paper›PMID 32098418›Full record

ReviewNutrients2020

Vitamin D and Endothelial Function.

Do-Houn Kim, Cesar A Meza, Holly Clarke, Jeong-Su Kim, Robert C Hickner

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05408273 (Vitamin D Effects on Microvascular Function and Cardiovascular Risk Factors on Postmenopausal Women), which is not on this map. Cited by 194 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed, 11 pooled it
31.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05408273 completednot on this map

Vitamin D Effects on Microvascular Function and Cardiovascular Risk Factors on Postmenopausal Women

TypeobservationalSponsorRio de Janeiro State UniversityRan2019 to 2021Enrolled88ConditionsMenopause Related Conditions, Vitamin D Deficiency, Cardiovascular DiseasesArmsBlood samples and Microvascular function assessment evaluated through laser-Doppler flowmetry by the LASER speckle contrast analysis (LASCA) device
3 · Its place in the literature

Who cites it

194 citing papers in PubMed, 11 syntheses or guidelines pooled it, 346 citations in OpenAlex.

  1. Pooled it
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  5. Association betweenPeerJ · 2023
    Pooled it
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  11. Pooled it
  12. Trial
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  14. Nitric-Oxide-Inducing Factors on Vitamin D Changes in Older People Susceptible to Suffer from Sarcopenia.International journal of environmental research and public health · 2022
    Trial
  15. Trial
  16. Vitamin DJournal of cachexia, sarcopenia and muscle · 2021
    Trial
  17. Trial
  18. Review
  19. [Interpretation of the Expert Consensus Statement on the Role of Vitamin D in Metabolic Health].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
  20. Article

134 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Do-Houn KimDepartment of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0002-7556-8632
Cesar A MezaDepartment of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0003-1173-9620
Holly ClarkeDepartment of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
Jeong-Su KimDepartment of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
Robert C HicknerDepartment of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
Florida State University · US

Funding

NHLBI NIH HHS 2R15HL113854-02
6 · The paper itself

Abstract

Vitamin D is known to elicit a vasoprotective effect, while vitamin D deficiency is a risk factor for endothelial dysfunction (ED). ED is characterized by reduced bioavailability of a potent endothelium-dependent vasodilator, nitric oxide (NO), and is an early event in the development of atherosclerosis. In endothelial cells, vitamin D regulates NO synthesis by mediating the activity of the endothelial NO synthase (eNOS). Under pathogenic conditions, the oxidative stress caused by excessive production of reactive oxygen species (ROS) facilitates NO degradation and suppresses NO synthesis, consequently reducing NO bioavailability. Vitamin D, however, counteracts the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase which produces ROS, and improves antioxidant capacity by enhancing the activity of antioxidative enzymes such as superoxide dismutase. In addition to ROS, proinflammatory mediators such as TNF-α and IL-6 are risk factors for ED, restraining NO and eNOS bioactivity and upregulating the expression of various atherosclerotic factors through the NF-κB pathway. These proinflammatory activities are inhibited by vitamin D by suppressing NF-κB signaling and production of proinflammatory cytokines. In this review, we discuss the diverse activities of vitamin D in regulating NO bioavailability and endothelial function.

Indexed as

AtherosclerosisClinical Trials as TopicDietary SupplementsEndothelium, VascularHumansNADPH OxidasesNitric OxideNitric Oxide Synthase Type IIIOxidative StressReactive Oxygen SpeciesSignal TransductionSuperoxide DismutaseTreatment OutcomeVitamin DVitamin D DeficiencyNADPH OxidasesNitric OxideNitric Oxide Synthase Type IIIReactive Oxygen SpeciesSuperoxide DismutaseVitamin Dcalcitriolendothelial dysfunctioneNOSinflammationnitric oxideNONOXoxidative stressROSvitamin D deficiency

Identifiers

PMID32098418
PMCPMC7071424
OpenAlexW3008602794

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.