ArticleScientific reports2020
Holothurians have a reduced GPCR and odorant receptor-like repertoire compared to other echinoderms.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 18 citations in OpenAlex.
- A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light-Sensitive R-Opsin.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Vitamin C Promoted Feeding and Growth Rate ofBiology · 2026Article
- The Remarkable Diversity of Vertebrate Bitter Taste Receptors: Recent Advances in Genomic and Functional Studies.International journal of molecular sciences · 2024Review
- Sea Cucumber Viscera Contains Novel Non-Holostane-Type Glycoside Toxins that Possess a Putative Chemical Defense Function.Journal of chemical ecology · 2024Article
- Chemical communication and its role in sexual selection across Animalia.Communications biology · 2023Review
- Article
- The Evolutionary History of Vertebrate Adhesion GPCRs and Its Implication on Their Classification.International journal of molecular sciences · 2021Article
- G protein-coupled receptors as candidates for modulation and activation of the chemical senses in decapod crustaceans.PloS one · 2021Article
- A computational model for GPCR-ligand interaction prediction.Journal of integrative bioinformatics · 2020Article
- Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus.BMC genomics · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sea cucumbers lack vision and rely on chemical sensing to reproduce and survive. However, how they recognize and respond to environmental cues remains unknown. Possible candidates are the odorant receptors (ORs), a diverse family of G protein-coupled receptors (GPCRs) involved in olfaction. The present study aimed at characterizing the chemosensory GPCRs in sea cucumbers. At least 246 distinct GPCRs, of which ca. 20% putative ORs, were found in a transcriptome assembly of putative chemosensory (tentacles, oral cavity, calcareous ring, and papillae/tegument) and reproductive (ovary and testis) tissues from Holothuria arguinensis (57 ORs) and in the Apostichopus japonicus genome (79 ORs). The sea cucumber ORs clustered with those of sea urchin and starfish into four main clades of gene expansions sharing a common ancestor and evolving under purifying selection. However, the sea cucumber ORs repertoire was the smallest among the echinoderms and the olfactory receptor signature motif LxxPxYxxxxxLxxxDxxxxxxxxP was better conserved in cluster OR-l1 which also had more members. ORs were expressed in tentacles, oral cavity, calcareous ring, and papillae/tegument, supporting their potential role in chemosensing. This study is the first comprehensive survey of chemosensory GPCRs in sea cucumbers, and provides the molecular basis to understand how they communicate.
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