ArticleMolecular psychiatry2020
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03170362 (PRIME Care), which is not on this map. Cited by 82 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 5 pooled it
15.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PRIME Care (PRecision Medicine In MEntal Health Care)
Who cites it
82 citing papers in PubMed, 5 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- Genome-wide meta-analyses of cross substance use disorders in diverse populations.Molecular psychiatry · 2026Pooled it
- Testing the causal relationships of physical activity and sedentary behaviour with mental health and substance use disorders: a Mendelian randomisation study.Molecular psychiatry · 2023Pooled it
- Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.Molecular psychiatry · 2022Pooled it
- Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction.Nature neuroscience · 2022Pooled it
- Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance.Translational psychiatry · 2022Pooled it
- Genetic variation in BDNF is associated with opioid use disorder severity.Human genetics · 2026Article
- Immune markers mediate genetic relationships between immune diseases and psychiatric disorders.PLoS genetics · 2026Article
- Cross-ancestry pleiotropic analysis of imaging-derived phenotypes enhances risk stratification of depression.Molecular psychiatry · 2026Article
- Review
- Opposing Ageing-Related Transcriptomic Profiles Distinguish Opioid Exposure Liability From Dependence Liability.Cureus · 2026Article
- Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Cornichon Homolog-3 (Cnih3) deletion impairs spatial memory, operant learning, and fentanyl self-administration behavior.Translational psychiatry · 2026Article
- Behavioral and transcriptomic markers of susceptibility to escalate fentanyl intake.Translational psychiatry · 2026Article
- Prenatal Alcohol Exposure and Mental Health Outcomes: A Two-Sample Mendelian Randomization Study of DNA Methylation Signatures.medRxiv : the preprint server for health sciences · 2026Article
- Multisystem regulation of reward and addiction: beyond the dopaminergic system.Frontiers in pharmacology · 2026Review
- Review
- Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases.Translational psychiatry · 2025Article
- Article
- Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders.Translational psychiatry · 2025Article
- The BioSUD Biobank as a genomic resource for substance use disorders in Italy.Scientific reports · 2025Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 19 institutions in 2 countries.
Renato PolimantiDepartment of Psychiatry, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA.
Raymond K WaltersAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8422-6530
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Jeanette N McClintickDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-6548-4902
Amy E AdkinsDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0002-3576-3759
Daniel E AdkinsDepartment of Psychiatry, University of Utah, Salt Lake City, UT, USA.
Silviu-Alin BacanuVirginia Commonwealth University Alcohol Research Center, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA.ORCID http://orcid.org/0000-0002-4364-1583
Laura J BierutDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Tim B BigdeliDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
Sandra BrownDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-8780-0323
Kathleen K BucholzDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
William E CopelandDepartment of Psychiatry, University of Vermont Medical Center, Burlington, VT, USA.
E Jane CostelloDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Louisa DegenhardtNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia.
Lindsay A FarrerDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Louis FoxDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Alison M GoateDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-0576-2472
Richard GruczaDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Laura M HackDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Dana B HancockCenter for Omics Discovery and Epidemiology, RTI International, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0003-2240-3604
Sarah M HartzDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-5429-3799
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
John K HewittInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Christian J HopferDepartment of Psychiatry, University of Colorado Denver, Aurora, CO, USA.
Eric O JohnsonCenter for Omics Discovery and Epidemiology, RTI International, Research Triangle Park, NC, USA.
Kenneth S KendlerVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Henry R KranzlerCenter for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, VISN 4 MIRECC, Crescenz VAMC, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1018-0450
Kenneth KrauterDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0001-7803-580X
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Hermine H MaesVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Elliot C NelsonDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-3037-3962
Roseann E PetersonDepartment of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Bernice PorjeszDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
Brien P RileyVirginia Commonwealth University Alcohol Research Center, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA.ORCID http://orcid.org/0000-0002-2408-8268
Nancy SacconeDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
Michael StallingsInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Tamara L WallDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Bradley T WebbVirginia Commonwealth University Alcohol Research Center, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA.ORCID http://orcid.org/0000-0002-0576-5366
Leah WetherillDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-2888-9051
Psychiatric Genomics Consortium Substance Use Disorders Workgroup
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-0344-9690
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-0313-793X
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA. joel.gelernter@yale.edu.ORCID http://orcid.org/0000-0002-4067-1859
Washington University in St. Louis · USVirginia Commonwealth University · USIndiana University School of MedicineRTI International · USUniversity of Colorado Boulder · USState University of New York · USUniversity of California San Diego · USYale University · USBoston University · USDuke Medical Center · USHarvard University · USIcahn School of Medicine at Mount Sinai · USQIMR Berghofer Medical Research Institute · AUStanford University · USUniversity of Colorado Denver · USUniversity of Pennsylvania · USUniversity of Utah · USUniversity of Vermont Medical Center · USUNSW Sydney · AU
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MTwin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5MTRANSLATION AND DISSEMINATION COREP30DA023026 · NIDA · DUKE UNIVERSITY · PI DODGE, KENNETH A · 2008 to 2023
$19.6MProject 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MICHAEL F MILES · 2014 to 2026
$19.6MThe Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3MSex-specific analysis of opioid dependence GWAS and beyondR01DA012690 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2000 to 2017
$14.0MPILOT--GENETIC EPIDEMIOLOGY OF ALCOHOL AND TOBACCO CONSUMPTION IN CHINESE SAMPLEP50AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1999 to 2008
$12.6MGENETICS OF COCAINE DEPENDENCER01DA012849 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1999 to 2010
$11.5MTHE GENETICS OF VULNERABILITY TO NICOTINE ADDICTIONSR01DA012854 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2000 to 2013
$10.4MThe Effects of Cannabis Legalization and Persistent Use: A Longitudinal Study of Two Twin CohortsR01DA042755 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Jarrod Martin Ellingson, SOO H RHEE · 2017 to 2026
$9.9MNCATS NIH HHS UL1 TR001863NCI NIH HHS P01 CA089392NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS N01 HG065403NHGRI NIH HHS U01 HG004422NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P20 AA017828NIAAA NIH HHS P50 AA011998NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA011330NIAAA NIH HHS R01 AA011408NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA014041NIAAA NIH HHS R01 AA017444NIAAA NIH HHS R01 AA017535NIAAA NIH HHS R21 AA022717NIAAA NIH HHS R21 AA024888NIAAA NIH HHS R37 AA007728NIAAA NIH HHS R37 AA011408NIAAA NIH HHS U10 AA008401NICHD NIH HHS R01 HD093651NIDA NIH HHS K02 DA032573NIDA NIH HHS K08 DA019951NIDA NIH HHS K08 DA032680NIDA NIH HHS K24 DA032555NIDA NIH HHS P30 DA023026NIDA NIH HHS P60 DA011015NIDA NIH HHS R01 DA011301NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012845NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA012854NIDA NIH HHS R01 DA013423NIDA NIH HHS R01 DA016977NIDA NIH HHS R01 DA017305NIDA NIH HHS R01 DA018432NIDA NIH HHS R01 DA019963NIDA NIH HHS R01 DA021905NIDA NIH HHS R01 DA021913NIDA NIH HHS R01 DA024413NIDA NIH HHS R01 DA025109NIDA NIH HHS R01 DA035804NIDA NIH HHS R01 DA036523NIDA NIH HHS R01 DA036583NIDA NIH HHS R01 DA042755NIDA NIH HHS R01 DA044014NIDA NIH HHS R21 DA047527NIDA NIH HHS R25 DA027995NIDA NIH HHS R33 DA047527NIDA NIH HHS R56 DA012854NIDA NIH HHS RC2 DA028909NIDA NIH HHS U01 DA024413NIMH NIH HHS K01 MH093731NIMH NIH HHS K01 MH113848NIMH NIH HHS K23 MH080230NIMH NIH HHS R01 MH048085NIMH NIH HHS R01 MH063671NIMH NIH HHS R01 MH063970NIMH NIH HHS R01 MH068521NIMH NIH HHS R01 MH100549NIMH NIH HHS R01 MH117559NIMH NIH HHS R01 MH124871NIMH NIH HHS U01 MH109528NIMH NIH HHS U01 MH109532
Abstract
To provide insights into the biology of opioid dependence (OD) and opioid use (i.e., exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173 opioid-exposed controls, and 32,500 opioid-unexposed controls, including participants of European and African descent (EUR and AFR, respectively). Among the variants identified, rs9291211 was associated with OE (exposed vs. unexposed controls; EUR z = -5.39, p = 7.2 × 10
Indexed as
Genome-Wide Association StudyGenomicsAnalgesics, OpioidBehavior, AddictiveFemaleGenetic Predisposition to DiseaseGenetic VariationGenome, HumanHumansMaleMultifactorial InheritanceOpioid-Related DisordersAnalgesics, Opioid
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
NCT03170362ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.