Evidence map›Paper›PMID 32101167›Full record

ArticleeLife2020

Ordered patterning of the sensory system is susceptible to stochastic features of gene expression.

Ritika Giri, Dimitrios K Papadopoulos, Diana M Posadas, Hemanth K Potluri, Pavel Tomancak, Madhav Mani, Richard W Carthew

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Bioenergetic costs and the evolution of noise regulation by microRNAs.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. A synthetic synthesis to explore animal evolution and development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Ritika GiriDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.ORCID 0000-0001-8838-0818
Dimitrios K PapadopoulosMax Planck Institute of Cell Biology and Genetics, Dresden, Germany.
Diana M PosadasDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.
Hemanth K PotluriDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.
Pavel TomancakMax Planck Institute of Cell Biology and Genetics, Dresden, Germany.ORCID 0000-0002-2222-9370
Madhav ManiDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.
Richard W CarthewDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.ORCID 0000-0003-0343-0156
Northwestern University · USInstitute of Genetics and Cancer · GBMax Planck Institute of Molecular Cell Biology and Genetics · DE

Funding

Non-coding RNAs and their mechanisms and functions-RenewalR35GM118144 · NIGMS · NORTHWESTERN UNIVERSITY · PI Richard W. CARTHEW · 2016 to 2026
$6.8M
National Science Foundation 1764421NIGMS NIH HHS R35 GM118144Simons Foundation 597491
6 · The paper itself

Abstract

Sensory neuron numbers and positions are precisely organized to accurately map environmental signals in the brain. This precision emerges from biochemical processes within and between cells that are inherently stochastic. We investigated impact of stochastic gene expression on pattern formation, focusing on

Indexed as

AllelesAnimalsDrosophila melanogasterDrosophila ProteinsFemaleGene Expression RegulationNuclear ProteinsSensory Receptor CellsStochastic ProcessesTranscription FactorsTranscription, GeneticDrosophila ProteinsNuclear Proteinssens protein, DrosophilaTranscription Factorsdevelopmental biologyD. melanogastergene expressionmicroRNAssensory developmentstochasticitytransvection

Identifiers

PMID32101167
PMCPMC7064346
OpenAlexW3008491420

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.