ArticleScientific reports2020
Development of a two-stage limb ischemia model to better simulate human peripheral artery disease.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Animal models of ischemic limb ulcers: a systematic review and meta-analysis.BMJ open diabetes research & care · 2020Pooled it
- Differential Myopathic and Transcriptomic Changes in Soleus and Gastrocnemius Muscles in a Novel Chronic Hindlimb Ischemia Rat Model Induced by Endovascular Catheter Occlusion.Acta physiologica (Oxford, England) · 2026Article
- Human Myeloid-Derived Growth Factor Induces a Pro-Angiogenic Response and Functional Recovery in a Mouse Model of Peripheral Artery Disease.International journal of molecular sciences · 2026Article
- Human Decellularized Adipose Tissue Hydrogels as a Delivery Platform to Enhance Human Endothelial Colony-Forming Cell Retention and Vascular Regeneration.Journal of functional biomaterials · 2026Article
- Investigating Age-Dependent Oxygenation and Blood Perfusion in a Mouse Model of Peripheral Artery Disease (PAD) Using Multispectral Optoacoustic Tomography (MSOT), Laser Speckle Contrast Imaging (LSCI) and Histology.Diagnostics (Basel, Switzerland) · 2026Article
- Development and characterization of rat hindlimb ischemia models mimicking peripheral arterial disease severity.Scientific reports · 2026Article
- The Mechanosensation-Metabolism-Inflammation Axis: The Central Role of Piezo1 and TRPV4 in Hypertension-Related Atherosclerosis.International journal of general medicine · 2026Review
- An injectable self-healing curcumin-sustained-release hydrogel for lower limb ischemia via autophagy inhibition byRegenerative biomaterials · 2026Article
- mRNA-basedMolecular therapy. Nucleic acids · 2025Article
- Comparative Analysis of Animal Models in Wound Healing Research and the Utility for Humanized Mice Models.Advances in wound care · 2025Review
- Effect of metformin in a novel experimental model of peripheral artery disease.Clinical science (London, England : 1979) · 2025Article
- A mouse model of deep vein thrombosis by inferior vena cava hypoperfusion using ameroid constrictors.Scientific reports · 2025Article
- A 6-Minute Limb Function Assessment for Therapeutic Testing in Experimental Peripheral Artery Disease Models.JACC. Basic to translational science · 2025Article
- Is Laser Doppler Perfusion Imaging Truly a "Gold Standard" for Preclinical Peripheral Artery Disease Research?JACC. Basic to translational science · 2025Article
- Bone Marrow Mesenchymal Stem Cells Overexpressing MicroRNA-126 to Treat Critical Limb Ischemia.MicroRNA (Shariqah, United Arab Emirates) · 2025Article
- What Is the Best Experimental Model for Developing Novel Therapeutics in Peripheral Artery Disease?Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- The rat as an animal model in chronic wound research: An update.Life sciences · 2024Review
- Power-Doppler Ultrasonic Imaging of Peripheral Perfusion in Diabetic Mice.IEEE transactions on bio-medical engineering · 2024Article
- Pathological Changes in the Gastrocnemius Muscle throughout Hind Limb Ischemia Modeling in Rats.Bulletin of experimental biology and medicine · 2024Article
- A 6-minute Limb Function Assessment for Therapeutic Testing in Experimental Peripheral Artery Disease Models.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral arterial disease (PAD) develops due to the narrowing or blockage of arteries supplying blood to the lower limbs. Surgical and endovascular interventions are the main treatments for advanced PAD but alternative and adjunctive medical therapies are needed. Currently the main preclinical experimental model employed in PAD research is based on induction of acute hind limb ischemia (HLI) by a 1-stage procedure. Since there are concerns regarding the ability to translate findings from this animal model to patients, we aimed to develop a novel clinically relevant animal model of PAD. HLI was induced in male Apolipoprotein E (ApoE
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.