Evidence map›Paper›PMID 32107313›Full record

ArticleThe Journal of biological chemistry2020

Structural basis of cell-surface signaling by a conserved sigma regulator in Gram-negative bacteria.

Jaime L Jensen, Beau D Jernberg, Sangita C Sinha, Christopher L Colbert

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jaime L JensenDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108.
Beau D JernbergDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108.
Sangita C SinhaDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108.
Christopher L ColbertDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108. Electronic address: Christopher.colbert@ndsu.edu.
North Dakota State University · US

Funding

Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
Time resolved SAXS studies on the RP2/Arl3 complex pp.484-485P41GM103622 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2012 to 2020
$11.9M
Pilot Projects: Core DP30GM103332 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI SIBI, MUKUND P. · 2012 to 2016
$4.9M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
Structural basis of sigma-regulator recognition by a site-1 protease during cell surface signaling by Gram-negative bacteria.R01GM126207 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI Christopher L Colbert · 2018 to 2026
$1.7M
Advanced Pixel Array Detector for Time-Resolved SAXS and Fiber DiffractionS10OD018090 · OD · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2014 to 2014
$529k
Elucidating the structural basis of differential interactions of human BECN paralogs and their role in cellular homeostasisR15GM122035 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI SINHA, SANGITA · 2017 to 2017
$435k
Mechanism of inner membrane sigma-regulator function in Gram-negative bacteriaR15GM113227 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI COLBERT, CHRISTOPHER L · 2015 to 2016
$408k
NCRR NIH HHS S10 RR029205NIGMS NIH HHS P30 GM103332NIGMS NIH HHS P41 GM103403NIGMS NIH HHS P41 GM103622NIGMS NIH HHS R01 GM126207NIGMS NIH HHS R15 GM113227NIGMS NIH HHS R15 GM122035NIH HHS S10 OD018090
6 · The paper itself

Abstract

Cell-surface signaling (CSS) in Gram-negative bacteria involves highly conserved regulatory pathways that optimize gene expression by transducing extracellular environmental signals to the cytoplasm via inner-membrane sigma regulators. The molecular details of ferric siderophore-mediated activation of the iron import machinery through a sigma regulator are unclear. Here, we present the 1.56 Å resolution structure of the periplasmic complex of the C-terminal CSS domain (CCSSD) of PupR, the sigma regulator in the

Indexed as

Signal TransductionBacterial Outer Membrane ProteinsCrystallography, X-RayModels, MolecularPeriplasmProtein ConformationProtein DomainsProtein Interaction MapsPseudomonasSiderophoresBacterial Outer Membrane ProteinsSiderophoresbacterial signal transductionbiophysicscell surface signalinginner membrane sigma regulatormetal homeostasisprotein structurestructural biologyTonB-dependent transducerX-ray crystallographyX-ray scattering

Identifiers

PMID32107313
PMCPMC7186176
OpenAlexW3006830057

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.