Evidence map›Paper›PMID 32108023›Full record

ArticleDevelopment (Cambridge, England)2020

Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of

Megan L Koth, S Alexandra Garcia-Moreno, Annie Novak, Kirsten A Holthusen, Anbarasi Kothandapani, Keer Jiang, Makoto Mark Taketo, Barbara Nicol, Humphrey H-C Yao, Christopher R Futtner and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Building a resilient ovarian reserve: Early soma-oocyte interactions.Current topics in developmental biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. The Characterization and Differential Analysis of mAnimals : an open access journal from MDPI · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Megan L KothDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin - Madison, Madison, WI 53706, USA.ORCID 0000-0003-3045-0101
S Alexandra Garcia-MorenoDepartment of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA.
Annie NovakDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin - Madison, Madison, WI 53706, USA.ORCID 0000-0002-2595-6776
Kirsten A HolthusenDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA.ORCID 0000-0002-8853-6066
Anbarasi KothandapaniDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin - Madison, Madison, WI 53706, USA.ORCID 0000-0001-9701-0800
Keer JiangDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin - Madison, Madison, WI 53706, USA.ORCID 0000-0001-6260-3796
Makoto Mark TaketoDepartment of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.ORCID 0000-0002-9032-4505
Barbara NicolReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.ORCID 0000-0002-3434-0658
Humphrey H-C YaoReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.ORCID 0000-0003-2944-8469
Christopher R FuttnerDepartment of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-3004-9983
Danielle M MaatoukDepartment of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA.
Joan S JorgensenDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin - Madison, Madison, WI 53706, USA joan.jorgensen@wisc.edu.ORCID 0000-0002-5787-8856
University of Wisconsin–Madison · USNorthwestern University · USNational Institute of Environmental Health Sciences · USKyoto University · JPUniversity of Illinois Urbana-Champaign · US

Funding

Impacts of Genetic and Environmental Factors on Reproductive Organ DevelopmentZIAES102965 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI YAO, HUMPHREY · 2011 to 2025
$32.8M
CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
Training Program In Molecular AND Cellular PharmacologyT32GM008688 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 1998 to 2020
$6.0M
Mediators for dynamic regulation of Star transcription in Leydig cellsR01HD090660 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI JEFCOATE, COLIN ROBERT, JORGENSEN, JOAN S · 2017 to 2021
$3.1M
IRXB Factors Direct Follicle MaturationR01HD075079 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI JORGENSEN, JOAN S · 2013 to 2017
$1.6M
Sexually Dimorphic Regulation Of SF-1 In GonadogenesisR21HD048911 · NICHD · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI JORGENSEN, JOAN S · 2005 to 2006
$403k
Intramural NIH HHS ZIA ES102965NICHD NIH HHS R01 HD075079NICHD NIH HHS R01 HD090660NICHD NIH HHS R21 HD048911NIGMS NIH HHS T32 GM008061NIGMS NIH HHS T32 GM008688
6 · The paper itself

Abstract

Members of the Iroquois B (IrxB) homeodomain cluster genes, specifically

Indexed as

Animalsbeta CateninCell DifferentiationCells, CulturedEmbryo, MammalianEpigenesis, GeneticFemaleGene Expression Regulation, DevelopmentalGonadsHomeodomain ProteinsMaleMiceMice, Inbred C57BLMice, Inbred ICRMice, TransgenicOvarybeta CateninHomeodomain ProteinsIrx3 protein, mouseIrx5 protein, mouseTranscription FactorsEnhancerEpigeneticsFetal gonadIroquoisWntβ-Catenin

Identifiers

PMID32108023
PMCPMC7132837
OpenAlexW3008166676

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.