Evidence map›Paper›PMID 32108714›Full record

ArticleThe Journal of head trauma rehabilitation

Dopamine-Related Genes Moderate the Association Between Family Environment and Executive Function Following Pediatric Traumatic Brain Injury: An Exploratory Study.

Julia Smith-Paine, Allison P Fisher, Shari L Wade, Nanhua Zhang, Huaiyu Zang, Lisa J Martin, Keith Owen Yeates, H Gerry Taylor, Brad G Kurowski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of head trauma rehabilitation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Julia Smith-PaineDivisions of Pediatric Rehabilitation Medicine (Ms Smith-Paine and Fisher and Drs Wade and Kurowski), Biostatistics and Epidemiology (Dr Zhang and Mr Zang), and Human Genetics (Dr Martin), Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Psychology, Alberta Children's Hospital Research Institute, and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (Dr Yeates); Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio (Dr Taylor); and Department of Pediatrics, The Ohio State University, Columbus (Dr Taylor).
Allison P Fisher
Shari L Wade
Nanhua Zhang
Huaiyu Zang
Lisa J Martin
Keith Owen Yeates
H Gerry Taylor
Brad G Kurowski
Alberta Children's Hospital · CA

Funding

Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
Long Term Functional Outcomes of Early TBIR01HD042729 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI WADE, SHARI L · 2002 to 2013
$5.2M
Genetic and Environmental Influences on Recovery of Severe Pediatric Brain Injury.R01NS096053 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI KUROWSKI, BRAD G · 2016 to 2020
$2.9M
NCATS NIH HHS UL1 TR000077NICHD NIH HHS R01 HD042729NINDS NIH HHS R01 NS096053
6 · The paper itself

Abstract

objectiveThis study examined whether carrying dopamine-related "risk" genes-either the dopamine transporter (DAT1) 10-repeat allele or dopamine receptor-4 (DRD4) 7-repeat allele-moderated the association of family environment and executive function (EF) following traumatic brain injury (TBI) in early childhood.

methodsCaregivers of children with TBI or orthopedic injury (OI) completed the Behavior Rating Inventory of Executive Function (BRIEF) at postinjury visits. General linear models examined gene by environment interactions as moderators of the effects of TBI on EF at 12 months and 7 years postinjury.

resultsAt 12 months, we did not find any significant gene by environment interactions. At 7 years, we found a significant 3-way interaction among combined carrier status, level of permissive parenting, and injury type. For children exposed to more optimal parenting, carriers of DAT1 and/or DRD4 risk alleles with TBI showed significantly worse parent-reported EF than carriers with OI. In those with less optimal parenting, carriers and noncarriers with TBI, as well as carriers with OI, showed significantly worse parent-reported EF than noncarriers with OI, with medium to large effect sizes.

conclusionsThe findings highlight the importance of considering polygenetic and environmental factors in future studies of recovery following TBI and other injuries in childhood.

Indexed as

Brain Injuries, TraumaticDopamineExecutive FunctionFamily CharacteristicsChildChild, PreschoolDopamine Plasma Membrane Transport ProteinsFemaleGene-Environment InteractionHumansInterpersonal RelationsMaleParentingReceptors, Dopamine D4DopamineDopamine Plasma Membrane Transport ProteinsDRD4 protein, humanReceptors, Dopamine D4SLC6A3 protein, human

Identifiers

PMID32108714
PMCPMC7485582
OpenAlexW3006761603

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.