Evidence map›Paper›PMID 32110026›Full record

ReviewNeuropsychiatric disease and treatment2020

Negative Symptoms in Schizophrenia: A Review and Clinical Guide for Recognition, Assessment, and Treatment.

Christoph U Correll, Nina R Schooler

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropsychiatric disease and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06127004 (Metacognitive Training for Negative Symptoms), which is not on this map. Cited by 439 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
439citing papers in PubMed, 19 pooled it
50.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06127004 narecruitingnot on this mapstarted 2024, after this paper: background citation

Metacognitive Training for Negative Symptoms (MCT Minus)

TypeinterventionalSponsorSormland County Council, SwedenRan2024 to 2032Enrolled90ConditionsNegative Symptoms in SchizophreniaArmsMetacognitive Training for Negative Symptoms (MCT), Supportive Counselling
3 · Its place in the literature

Who cites it

439 citing papers in PubMed, 19 syntheses or guidelines pooled it, 779 citations in OpenAlex.

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  7. The Australian and New Zealand journal of psychiatry · 2026
    Guideline
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  16. Systematic review of risk factors for violence in psychosis: 10-year update.The British journal of psychiatry : the journal of mental science · 2025
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379 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Christoph U CorrellThe Zucker Hillside Hospital, Division of Psychiatry Research, Northwell Health, Glen Oaks, NY, USA.ORCID 0000-0002-7254-5646
Nina R SchoolerState University of New York, Downstate Medical Center, Brooklyn, NY, USA.
Northwell Health · USState University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia is frequently a chronic and disabling disorder, characterized by heterogeneous positive and negative symptom constellations. The objective of this review was to provide information that may be useful for clinicians treating patients with negative symptoms of schizophrenia. Negative symptoms are a core component of schizophrenia that account for a large part of the long-term disability and poor functional outcomes in patients with the disorder. The term negative symptoms describes a lessening or absence of normal behaviors and functions related to motivation and interest, or verbal/emotional expression. The negative symptom domain consists of five key constructs: blunted affect, alogia (reduction in quantity of words spoken), avolition (reduced goal-directed activity due to decreased motivation), asociality, and anhedonia (reduced experience of pleasure). Negative symptoms are common in schizophrenia; up to 60% of patients may have prominent clinically relevant negative symptoms that require treatment. Negative symptoms can occur at any point in the course of illness, although they are reported as the most common first symptom of schizophrenia. Negative symptoms can be primary symptoms, which are intrinsic to the underlying pathophysiology of schizophrenia, or secondary symptoms that are related to psychiatric or medical comorbidities, adverse effects of treatment, or environmental factors. While secondary negative symptoms can improve as a consequence of treatment to improve symptoms in other domains (ie, positive symptoms, depressive symptoms or extrapyramidal symptoms), primary negative symptoms generally do not respond well to currently available antipsychotic treatment with dopamine D

Indexed as

clinical presentationdiagnosisnegative symptomsprevalenceschizophreniatreatment

Identifiers

PMID32110026
PMCPMC7041437
OpenAlexW3007830452

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.