Evidence map›Paper›PMID 32111739›Full record

ReviewThe Journal of biological chemistry2020

Viruses go modular.

Ariel Shepley-McTaggart, Hao Fan, Marius Sudol, Ronald N Harty

Abstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Chaperone-assisted selective autophagy targets filovirus VP40 as a client and restricts egress of virus particles.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Compound FC-10696 Inhibits Egress of Marburg Virus.Antimicrobial agents and chemotherapy · 2021
    Article
  13. Review
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ariel Shepley-McTaggartDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Hao FanBioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671.
Marius SudolDepartment of Physiology, National University of Singapore, Singapore 119077.
Ronald N HartyDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 rharty@vet.upenn.edu.ORCID 0000-0001-6596-0414

Funding

VMD-PhD Training in Infectious Disease-Related ResearchT32AI070077 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Michael Lee Atchison · 2008 to 2026
$3.5M
Development of Small Molecule Therapeutics Targeting Hemorrhagic Fever VirusesR42AI138630 · NIAID · FOX CHASE CHEMICAL DIVERSITY CENTER, INC · PI HARTY, RONALD N · 2021 to 2023
$3.0M
Host-Oriented Therapeutics Targeting Filovirus Budding.R33AI102104 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HARTY, RONALD N · 2014 to 2016
$1.4M
Development of Small Molecule Therapeutics Targeting Hemorrhagic Fever VirusesR41AI138630 · NIAID · FOX CHASE CHEMICAL DIVERSITY CENTER, INC · PI HARTY, RONALD N · 2018 to 2019
$597k
Dueling PPxY Motifs of Filovirus VP40 and Host Angiomotin: Effects on Innate Immune Defenses and Tight Junction Integrity at Immune Privileged SitesR21AI139392 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HARTY, RONALD N · 2018 to 2019
$462k
Modular Domains of Host Proteins Regulate Filovirus MaturationR21AI138052 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HARTY, RONALD N · 2018 to 2019
$448k
Host-Oriented Therapeutics Targeting Filovirus Budding.R21AI102104 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HARTY, RONALD N · 2012 to 2013
$423k
NIAID NIH HHS R21 AI102104NIAID NIH HHS R21 AI138052NIAID NIH HHS R21 AI139392NIAID NIH HHS R33 AI102104NIAID NIH HHS R41 AI138630NIAID NIH HHS R42 AI138630NIAID NIH HHS T32 AI070077
6 · The paper itself

Abstract

The WW domain is a modular protein structure that recognizes the proline-rich Pro-Pro-x-Tyr (PPxY) motif contained in specific target proteins. The compact modular nature of the WW domain makes it ideal for mediating interactions between proteins in complex networks and signaling pathways of the cell (

Indexed as

Amino Acid MotifsDNA VirusesHost-Pathogen InteractionsHumansRNA VirusesUbiquitin-Protein LigasesViral Matrix ProteinsVirusesVirus InternalizationWW DomainsUbiquitin-Protein LigasesViral Matrix Proteinsantiviral agentantiviral therapeuticbuddingE3 ubiquitin ligaseEbola virushost-oriented inhibitorsL domainmicrobiologymodular domainsPPxY motifviral life cyclevirusvirus buddingvirus-host interactionvirus-like particle (VLP)WW domain

Identifiers

PMID32111739
PMCPMC7135987

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.