Evidence map›Paper›PMID 32117244›Full record

ArticleFrontiers in immunology2020

Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection.

Kazuhito Honjo, Woong-Jai Won, Rodney G King, Lara Ianov, David K Crossman, Juliet L Easlick, Mikhail A Shakhmatov, Mohamed Khass, Andre M Vale, Robert P Stephan and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Evidence for Extensive Duplication and Subfunctionalization ofInternational journal of molecular sciences · 2023
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Kazuhito HonjoDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Woong-Jai WonDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Rodney G KingDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Lara IanovCivitan International Research Center, University of Alabama at Birmingham, Birmingham, AL, United States.
David K CrossmanDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, United States.
Juliet L EaslickDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Mikhail A ShakhmatovDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Mohamed KhassDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Andre M ValeProgram in Immunobiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Robert P StephanDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Ran LiDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Randall S DavisDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · USCivitan International · USUniversidade Federal do Rio de Janeiro · BR

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
Roles of FCRL Molecules in Innate ImmunityR01AI110553 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVIS, RANDALL S · 2015 to 2019
$1.7M
NCI NIH HHS P30 CA013148NIAID NIH HHS R01 AI110553NIAMS NIH HHS P30 AR048311
6 · The paper itself

Abstract

B-1a cells produce "natural" antibodies (Abs) to neutralize pathogens and clear neo self-antigens, but the fundamental selection mechanisms that shape their polyreactive repertoires are poorly understood. Here, we identified a B cell progenitor subset defined by Fc receptor-like 6 (FCRL6) expression, harboring innate-like defense, migration, and differentiation properties conducive for natural Ab generation. Compared to FCRL6

Indexed as

AnimalsAntibodiesB-LymphocytesCell DifferentiationFemaleHumansImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutPhosphatidylcholinesPrecursor Cells, B-LymphoidReceptors, Antigen, B-CellReceptors, FcSignal TransductionAntibodiesImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionPhosphatidylcholinesReceptors, Antigen, B-CellReceptors, Fcantibody repertoireautoimmunityB-1 cellschronic lymphocytic leukemiainnate-like B cellslymphocyte developmentlymphocyte selectionnatural antibodies

Identifiers

PMID32117244
PMCPMC7033751
OpenAlexW3005865750

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.