Evidence map›Paper›PMID 32131527›Full record

ArticleJournal of clinical medicine2020

Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial.

Abraham H Hulst, Maarten J Visscher, Thomas G V Cherpanath, Lieke van de Wouw, Marc B Godfried, Bram Thiel, Bastiaan M Gerritse, Thierry V Scohy, R Arthur Bouwman, Mark G A Willemsen and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Observational
  5. Observational
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Abraham H HulstDepartment of Anesthesiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-9101-7649
Maarten J VisscherDepartment of Anesthesiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1105 AZ Amsterdam, The Netherlands.
Thomas G V CherpanathDepartment of Intensive Care, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1105 AZ Amsterdam, The Netherlands.
Lieke van de WouwDepartment of Anesthesiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1105 AZ Amsterdam, The Netherlands.
Marc B GodfriedDepartment of Anesthesiology, OLVG, Oosterpark 9, 1091 AC Amsterdam, The Netherlands.
Bram ThielDepartment of Anesthesiology, OLVG, Oosterpark 9, 1091 AC Amsterdam, The Netherlands.
Bastiaan M GerritseDepartment of Anesthesiology, Amphia, Molengracht 21, 4818 CK Breda, The Netherlands.
Thierry V ScohyDepartment of Anesthesiology, Amphia, Molengracht 21, 4818 CK Breda, The Netherlands.
R Arthur BouwmanDepartment of Anesthesiology, Catharina Hospital, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands.
Mark G A WillemsenDepartment of Anesthesiology, Catharina Hospital, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands.
Markus W HollmannDepartment of Anesthesiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1105 AZ Amsterdam, The Netherlands.
J Hans DeVriesDepartment of Endocrinology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1105 AZ Amsterdam, The Netherlands.
Benedikt PreckelDepartment of Anesthesiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-4412-9183
Jeroen HermanidesDepartment of Anesthesiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1105 AZ Amsterdam, The Netherlands.
Amsterdam University Medical Centers · NLAmphia Ziekenhuis · NLRadboud University Nijmegen · NL

Funding

Novo Nordisk not applicable
6 · The paper itself

Abstract

introductionPrevious studies demonstrated the cardioprotective properties of glucagon-like peptide-1 receptor agonists in patients with diabetes or cardiac disease. We investigated whether preoperative subcutaneous liraglutide improves myocardial function after cardiac surgery.

methodsWe performed a pre-planned secondary analysis of adult patients undergoing cardiac surgery included in the GLOBE trial. Patients were randomised to receive 0.6 mg subcutaneous liraglutide on the evening before surgery and 1.2 mg after induction of anaesthesia, or matching placebo. Perioperative echocardiographic assessments, haemodynamic parameters, doses of vasoactive inotropic support and postoperative measurements of troponin, Creatine Kinase-MB , creatinine and lactate were compared between groups.

resultsThe study population consisted of the entire intention-to-treat cohort of the GLOBE trial. In this study, 129 patients received liraglutide and 132 patients placebo. Baseline characteristics were comparable between groups. Postoperatively, 170 (65%) patients underwent echocardiography. In the liraglutide group, more patients had a normal left ventricular systolic function (68%, 59 patients) compared to placebo (53%, 44 patients), difference = 15%, 95%CI = 0-30,

conclusionsPatients receiving short-term preoperative liraglutide treatment better maintained normal myocardial function after cardiac surgery. This study warrants further evaluation of the potential beneficial effects of GLP-1 receptor agonists in cardiac surgery patients.

Indexed as

cardiac functionCK-MBechocardiographyleft ventricular functionliraglutideplaceborandomised controlled trialTroponin

Identifiers

PMID32131527
PMCPMC7141279
OpenAlexW3009351595

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.