ArticleCurrent addiction reports2019
Measuring Within-Individual Cannabis Reduction in Clinical Trials: A Review of the Methodological Challenges.
Article in Current addiction reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Health education interventions to reduce cannabis and tobacco smoking-related harms among people who use cannabis: a systematic review.Health education research · 2026Pooled it
- Identifying brief intervention factors to improve cannabis related outcomes in adolescents and young adults: A systematic review of sample characteristics and intervention components.Journal of substance use and addiction treatment · 2024Pooled it
- Characterizing cannabis use reduction and change in functioning during treatment: Initial steps on the path to new clinical endpoints.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Trial
- Telehealth-Plus-mHealth Intervention for Young Adults With Cannabis Use Disorder: Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2026Article
- Cannabis and Polypharmacy Leading to Hospitalization for Acute Confusion and Inability to Ambulate.Cureus · 2025Article
- Association of Cannabis Use Reduction With Improved Functional Outcomes: An Exploratory Aggregated Analysis From Seven Cannabis Use Disorder Treatment Trials to Extract Data-Driven Cannabis Reduction Metrics.The American journal of psychiatry · 2024Article
- Urgent need for treatment addressing co-use of tobacco and cannabis: An updated review and considerations for future interventions.Addictive behaviors · 2024Review
- Tobacco, Alcohol, and Drug Use Among Young Adults with Serious Mental Illness.Community mental health journal · 2024Article
- Exploring survey methods for measuring consumption quantities of cannabis flower and concentrate products.The American journal of drug and alcohol abuse · 2023Article
- Implementation and Preliminary Evaluation of a 12-Week Cognitive Behavioural and Motivational Enhancement Group Therapy for Cannabis Use Disorder.Substance abuse : research and treatment · 2023Article
- Measuring recent cannabis use across modes of delivery: Development and validation of the Cannabis Engagement Assessment.Addictive behaviors reports · 2022Article
- Treatment Implications Associated with Cannabis and Tobacco Co-Use.Current addiction reports · 2020Article
- Proceedings of the 2025 Cannabis Clinical Outcomes Research Conference.Medical cannabis and cannabinoidsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeCannabis abstinence traditionally is the primary outcome in cannabis use disorder (CUD) treatment trials. Due to the changing legality of cannabis, patient goals, and preliminary evidence that suggests individuals who reduce their cannabis use may show functional improvements, cannabis reduction is a desirable alternative outcome in CUD trials. We review challenges in measuring cannabis reduction and the evidence to support various definitions of reduction.
findingsReduction in number of cannabis use days was associated with improvements in functioning across several studies. Reductions in quantity of cannabis used was inconsistently associated with improvements in functioning, though definitions of quantity varied across studies. Different biomarkers may be used depending on the reduction outcome.
conclusionsBiologically-confirmed reductions in frequency of cannabis use days may represent a viable endpoint in clinical trials for cannabis use disorder. Additional research is needed to better quantify reduction in cannabis amounts.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.