Evidence map›Paper›PMID 32138265›Full record

ArticleBiomolecules2020

Homocysteine Induces Inflammation in Retina and Brain.

Nehal M Elsherbiny, Isha Sharma, Dina Kira, Suhib Alhusban, Yara A Samra, Ravirajsinh Jadeja, Pamela Martin, Mohamed Al-Shabrawey, Amany Tawfik

Abstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. B Vitamins and Ocular Health.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.Journal of the American Heart Association · 2024
    Article
  18. Review
  19. Article
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nehal M ElsherbinyDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Isha SharmaDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Dina KiraDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Suhib AlhusbanDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Yara A SamraDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Ravirajsinh JadejaJames and Jean Culver Vision Discovery Institute, MCG, Augusta University, Augusta, GA 30912, USA.
Pamela MartinJames and Jean Culver Vision Discovery Institute, MCG, Augusta University, Augusta, GA 30912, USA.
Mohamed Al-ShabraweyDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Amany TawfikDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.

Funding

Molecular basis of inflammation in retina, and novel strategies for limiting itR01EY022704 · NEI · AUGUSTA UNIVERSITY · PI MARTIN, PAMELA M · 2014 to 2018
$2.2M
Homocysteine's role in Age-Related Macular DegenerationR01EY029751 · NEI · OAKLAND UNIVERSITY · PI TAWFIK, AMANY M · 2019 to 2023
$1.8M
American Heart Association #16SDG3070001NEI NIH HHS R01 EY022704NEI NIH HHS R01 EY029751
6 · The paper itself

Abstract

Homocysteine (Hcy) is an amino acid that requires vitamins B

Indexed as

Alzheimer DiseaseAnimalsBrainDiabetic RetinopathyHomocysteineHumansInflammationMacular DegenerationMiceMice, KnockoutRetinaU937 CellsHomocysteineage-related macular degenerationAlzheimer’s diseasediabetic retinopathyhomocysteineinflammation

Identifiers

PMID32138265
PMCPMC7175372

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.