Evidence map›Paper›PMID 32138279›Full record

ArticleInternational journal of molecular sciences2020

Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia.

Jonathon L Payne, Chunhua Song, Yali Ding, Pavan Kumar Dhanyamraju, Yevgeniya Bamme, Joseph W Schramm, Dhimant Desai, Arati Sharma, Chandrika Gowda, Sinisa Dovat

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. IKAROS in Acute Leukemia: A Positive Influencer or a Mean Hater?International journal of molecular sciences · 2023
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jonathon L PayneSchool of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.ORCID 0000-0001-7891-2921
Chunhua SongWexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-4081-2543
Yali DingCollege of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Pavan Kumar DhanyamrajuCollege of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.ORCID 0000-0001-9336-9402
Yevgeniya BammeCollege of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.ORCID 0000-0003-0777-0908
Joseph W SchrammCollege of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Dhimant DesaiCollege of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Arati SharmaCollege of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Chandrika GowdaCollege of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Sinisa DovatCollege of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Pennsylvania State University · USThe Ohio State University Wexner Medical Center · US

Funding

Targeting CRLF2 and Ikaros Alterations to Reduce Health Disparities in Childhood LeukemiaR01CA209829 · NCI · LOMA LINDA UNIVERSITY · PI DOVAT, SINISA, DUERKSEN-HUGHES, PENELOPE J · 2016 to 2020
$2.0M
Targeting CK2 oncogenic pathway to overcome drug resistance in high-risk leukemiaR01CA213912 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI DOVAT, SINISA · 2017 to 2021
$1.8M
Epigenetic Regulation in High-Risk LeukemiaF30CA221109 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI PAYNE, JONATHON · 2017 to 2020
$197k
Four Diamonds Fund Endowed ChairHyundai Hope On Wheels Scholar Hope GrantNCI NIH HHS CA209829NCI NIH HHS CA213912NCI NIH HHS CA221109NCI NIH HHS F30 CA221109NCI NIH HHS R01 CA209829NCI NIH HHS R01 CA213912St. Baldrick's Foundation Scholar Grant
6 · The paper itself

Abstract

Ikaros is a DNA-binding protein that regulates gene expression and functions as a tumor suppressor in B-cell acute lymphoblastic leukemia (B-ALL). The full cohort of Ikaros target genes have yet to be identified. Here, we demonstrate that Ikaros directly regulates expression of the small GTPase, Rab20. Using ChIP-seq and qChIP we assessed Ikaros binding and the epigenetic signature at the RAB20 promoter. Expression of Ikaros, CK2, and

Indexed as

Acute DiseaseCell Line, TumorHumansIkaros Transcription FactorPrecursor Cell Lymphoblastic Leukemia-LymphomaPromoter Regions, Geneticrab GTP-Binding ProteinsSignal TransductionIkaros Transcription FactorIKZF1 protein, humanRab20 protein, humanrab GTP-Binding ProteinsB-ALLCK2IkarosPP1RAB20

Identifiers

PMID32138279
PMCPMC7084408
OpenAlexW3009682980

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.